M
Mark J. Howard
Researcher at University of Leeds
Publications - 16
Citations - 229
Mark J. Howard is an academic researcher from University of Leeds. The author has contributed to research in topics: Metabolome & Pyridine. The author has an hindex of 6, co-authored 16 publications receiving 128 citations. Previous affiliations of Mark J. Howard include University of Western Australia & University of Kent.
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Journal ArticleDOI
Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein.
Prashant Bharadwaj,Prashant Bharadwaj,Tanya Solomon,Chris J. Malajczuk,Ricardo L. Mancera,Mark J. Howard,Damien W. M. Arrigan,Phillip Newsholme,Ralph N. Martins,Ralph N. Martins,Ralph N. Martins +10 more
TL;DR: The aim of this review is to highlight and summarize recent literature that have contributed insight into the implications of altered membrane composition on amyloid precursor protein (APP) proteolysis, production of Aβ, its internalization in to cells via permeabilization and receptor mediated uptake.
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Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells.
Prashant Bharadwaj,Prashant Bharadwaj,Tanya Solomon,Bikash R. Sahoo,Katarzyna Ignasiak,Scott Gaskin,Joanne Rowles,Giuseppe Verdile,Giuseppe Verdile,Mark J. Howard,Mark J. Howard,Charles S. Bond,Ayyalusamy Ramamoorthy,Ralph N. Martins,Ralph N. Martins,Philip Newsholme +15 more
TL;DR: It is demonstrated that hIAPP promotes Aβ oligomerization and formation of small oligomer and large aggregate heterocomplexes, and rIAPP exhibited reductions in Aβ induced neuronal cell death that was independent of its ability to interact with Aβ and form heterocom complex; suggesting mediation by other pathways.
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A family of small, cyclic peptides buried in preproalbumin since the Eocene epoch
Mark F. Fisher,Jingjing Zhang,Nicolas L. Taylor,Mark J. Howard,Oliver Berkowitz,Aleksandra W. Debowski,Bahar Behsaz,James Whelan,Pavel A. Pevzner,Joshua S. Mylne +9 more
TL;DR: This study has revealed what is likely to be a very large new family of orbitides, uniquely buried alongside albumin and processed by asparaginyl endopeptidase (AEP).
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NMR metabolomics reveals effects of Cryptosporidium infections on host cell metabolome
Christopher N. Miller,Charalampos Panagos,Charalampos Panagos,William R. T. Mosedale,Martin Kváč,Mark J. Howard,Mark J. Howard,Anastasios D. Tsaousis +7 more
TL;DR: Using a 1H nuclear magnetic resonance approach to metabolomics, the nature of the mouse gut metabolome is explored as well as providing the first insight into the metabolome of an infected cell line, which will spearhead understanding of the Cryptosporidium-host metabolic exchange and provide novel targets for tackling this deadly parasite.
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Supramolecular Self-Sorting Networks using Hydrogen-Bonding Motifs.
Heather M. Coubrough,Stephanie C. C. van der Lubbe,Kristina Hetherington,Aisling Minard,Christopher M. Pask,Mark J. Howard,Célia Fonseca Guerra,Célia Fonseca Guerra,Andrew J. Wilson +8 more
TL;DR: Examination of the interactions between individual components, experimentally and computationally, provided a rationale for the product distribution during each phase of a cascade, resulting in the construction of a biomimetic network in which the presence or absence of different components provides multiple unique pathways to distinct self‐sorted configurations.