Mark L. Dallas

TL;DR: CBD was found to act upon a number of targets that are linked to neurological therapeutics but that its actions were not consistent with modulation of such targets that would derive a therapeutically beneficial outcome.

TL;DR: A central role for AMPK is demonstrated in stimulus-response coupling by hypoxia and a link between metabolic stress and ion channel regulation in an O2-sensing system is identified for the first time.

TL;DR: The molecular and cellular responses toHypoxia contribute to the understanding of the clinical association of hypoxia and increased incidence of AD, and it remains to be determined whether inhibition of one or more of the effects of Hypoxia may be of benefit in arresting the development of this neurodegenerative disease.

TL;DR: It is shown that pharmacological restoration of AMPK activity not only abrogates the lipid accumulation observed in virus-infected and subgenomic replicon-harboring cells but also efficiently inhibits viral replication.

TL;DR: The data indicate that the cardioprotective effects of HO-1 activity may be attributable to an inhibitory action of CO on cardiac L-type Ca2+ channels, which arises from the ability of CO to promote generation of reactive oxygen species from complex III of mitochondria.