M
Mark L. Johnson
Researcher at University of Missouri–Kansas City
Publications - 91
Citations - 6747
Mark L. Johnson is an academic researcher from University of Missouri–Kansas City. The author has contributed to research in topics: Wnt signaling pathway & Osteocyte. The author has an hindex of 35, co-authored 91 publications receiving 6268 citations. Previous affiliations of Mark L. Johnson include Creighton University & University of Akron.
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Journal ArticleDOI
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.
Randall D. Little,John P. Carulli,Richard G. Del Mastro,Josée Dupuis,Mark Osborne,Colleen Folz,Susan P. Manning,Pamela Marie Swain,Shan Chuan Zhao,Brenda K. Eustace,Michelle M. Lappe,Lia Spitzer,Susan Zweier,Karen Braunschweiger,Youssef Benchekroun,Xintong Hu,Ronald Adair,Linda Chee,Michael Fitzgerald,Craig Tulig,Anthony Caruso,Nia Tzellas,Alicia Bawa,Barbara Franklin,Shannon M. McGuire,Shannon M. McGuire,Xavier Nogués,Xavier Nogués,Gordon Gong,Kristina Allen,Anthony Anisowicz,Arturo Morales,Peter T. Lomedico,Susan M. Recker,Paul Van Eerdewegh,Robert R. Recker,Mark L. Johnson +36 more
TL;DR: It is suggested that the HBM mutation confers a unique osteogenic activity in bone remodeling, and this understanding may facilitate the development of novel therapies for the treatment of osteoporosis.
Journal ArticleDOI
Osteocytes, mechanosensing and Wnt signaling.
TL;DR: The study of osteocyte biology is becoming an intense area of research interest and this review will examine some of the recent findings that are reshaping the understanding of bone/bone cell biology.
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Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone
John A. Robinson,Moitreyee Chatterjee-Kishore,Paul J. Yaworsky,Diane M. Cullen,Weiguang Zhao,Christine Li,Yogendra P. Kharode,Linda Sauter,Philip Babij,Eugene L. Brown,Andrew A. Hill,Mohammed P. Akhter,Mark L. Johnson,Robert R. Recker,Barry S. Komm,Frederick J. Bex +15 more
TL;DR: In vivo and in vitro mechanical loading results support that Wnt/β-catenin signaling is a normal physiological response to load and that activation of the Wnt /β- catenin pathway enhances the sensitivity of osteoblasts/osteocytes to mechanical loading.
Journal ArticleDOI
Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13)
Mark L. Johnson,Guodong Gong,William J. Kimberling,Susan M. Recker,Donald B. Kimmel,Robert R. Recker +5 more
TL;DR: HBM demonstrates the utility of spinal Z(BMD) as a quantitative bone phenotype that can be used for linkage analysis, and determines whether a single gene with different alleles that determine a wide range of peak bone densities exists in this region of chromosome 11.
Journal ArticleDOI
LRP5 and Wnt signaling: a union made for bone.
TL;DR: The main points of the current understanding of LRP5, Wnt’s and Wnt signaling, and the role they may play in bone are summarized.