Osteocytes, mechanosensing and Wnt signaling.
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TLDR
The study of osteocyte biology is becoming an intense area of research interest and this review will examine some of the recent findings that are reshaping the understanding of bone/bone cell biology.About:
This article is published in Bone.The article was published on 2008-04-01 and is currently open access. It has received 989 citations till now. The article focuses on the topics: Osteocyte & Bone cell.read more
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The Amazing Osteocyte
TL;DR: Osteocytes compose 90% to 95% of all bone cells in adult bone and are the longest lived bone cell, up to decades within their mineralized environment.
Journal ArticleDOI
WNT signaling in bone homeostasis and disease: from human mutations to treatments
Roland Baron,Michaela Kneissel +1 more
TL;DR: Current understanding of the mechanisms by which WNT signalng regulates bone homeostasis is reviewed, finding the pathway is now the target for therapeutic intervention to restore bone strength in millions of patients at risk for fracture.
Journal ArticleDOI
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Rinaldo Florencio-Silva,Gisela Rodrigues da Silva Sasso,Estela Sasso-Cerri,Manuel Simões,Paulo Sérgio Cerri +4 more
TL;DR: Current data about the structure and functions of bone cells and the factors that influence bone remodeling are discussed, indicating the dynamic nature of bone tissue.
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Biomimetic Systems for Hydroxyapatite Mineralization Inspired By Bone and Enamel
Liam C. Palmer,Christina J. Newcomb,Stuart R. Kaltz,Erik David Spoerke,Erik David Spoerke,Samuel I. Stupp +5 more
TL;DR: This review focuses on the formation of hydroxyapatite in synthetic systems designed primarily in the biomimetic context of bone or enamel mineralization for therapeutic approaches in repair of human tissues.
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The Osteocyte: An Endocrine Cell … and More
TL;DR: The osteocytes encased within mineralized bone matrix are actually multifunctional cells with many key regulatory roles in bone and mineral homeostasis and should be considered in new strategies to prevent and treat bone disease.
References
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β‐catenin is a target for the ubiquitin–proteasome pathway
TL;DR: It is shown that ubiquitination of β‐catenin is greatly reduced in Wnt‐expressing cells, providing the first evidence that the ubiquitin–proteasome degradation pathway may act downstream of GSK3β in the regulation ofβ‐ catenin.
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TL;DR: The role and the molecular mechanism of action of regulatory molecules, such as cytokines and hormones, in osteoclast and osteoblast birth and apoptosis are reviewed to review the evidence for the contribution of changes in bone cell birth or death to the pathogenesis of the most common forms of osteoporosis.
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LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development
Yaoqin Gong,R. B. Slee,Naomi Fukai,Georges Rawadi,Sergio Roman-Roman,Anthony M. Reginato,H. W. Wang,Tim Cundy,Francis H. Glorieux,Dorit Lev,M. Zacharin,Konrad Oexle,Jose Marcelino,Wafaa M. Suwairi,Shauna Heeger,G. Sabatakos,Suneel S. Apte,W. N. Adkins,J. Allgrove,M. Arslan-Kirchner,J. A. Batch,Peter Beighton,Graeme C.M. Black,R. G. Boles,L. M. Boon,C. Borrone,Han G. Brunner,G. F. Carle,Bruno Dallapiccola,A. De Paepe,B. Floege,M. L. Halfhide,Barbara Hall,Raoul C.M. Hennekam,Tatsuo Hirose,A. Jans,Harald Jüppner,Chong Ae Kim,K. Keppler-Noreuil,A. Kohlschuetter,Didier Lacombe,M. Lambert,E. Lemyre,T. Letteboer,Leena Peltonen,Rajkumar Ramesar,M. Romanengo,H. Somer,E. Steichen-Gersdorf,Beat Steinmann,Beth A. Sullivan,Andrea Superti-Furga,W. Swoboda,M. J. van den Boogaard,W. Van Hul,Miikka Vikkula,Marcela Votruba,Bernhard Zabel,Teresa Garcia,Roland Baron,Bjorn R. Olsen,Matthew L. Warman +61 more
TL;DR: It is reported that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth and is important for the establishment of peak bone mass.
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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Surya M. Nauli,Francis J. Alenghat,Ying Luo,Eric O. Williams,Peter M. Vassilev,Xiaogang Li,Andrew E. H. Elia,Weining Lu,Edward M. Brown,Stephen J. Quinn,Donald E. Ingber,Jing Zhou +11 more
TL;DR: PC1 and PC2 contribute to fluid-flow sensation by the primary cilium in renal epithelium and that they both function in the same mechanotransduction pathway, suggesting loss or dysfunction of PC1 or PC2 may lead to polycystic kidney disease.
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Bone “mass” and the “mechanostat”: A proposal
TL;DR: The observed fit of bone mass to a healthy animal's typical mechanical usage indicates some mechanism or mechanisms monitor that usage and control the three longitudinal growth, bone modeling, and BMU‐based remodeling activities that directly determine bone mass.