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Mark O. Cunningham
Researcher at Newcastle University
Publications - 82
Citations - 5297
Mark O. Cunningham is an academic researcher from Newcastle University. The author has contributed to research in topics: Kainate receptor & Entorhinal cortex. The author has an hindex of 36, co-authored 77 publications receiving 4774 citations. Previous affiliations of Mark O. Cunningham include University of Leeds & University of Newcastle.
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Journal ArticleDOI
A SLM2 Feedback Pathway Controls Cortical Network Activity and Mouse Behavior
Ingrid Ehrmann,Matthew R. Gazzara,Vittoria Pagliarini,Caroline Dalgliesh,Mahsa Kheirollahi-Chadegani,Yaobo Xu,Eleonora Cesari,Marina Danilenko,Marie MacLennan,Kate Lowdon,Tanja Vogel,Piia Keskivali-Bond,Sara Wells,Heather Cater,Philippe Fort,Mauro Santibanez-Koref,Silvia Middei,Claudio Sette,Gavin J. Clowry,Yoseph Barash,Mark O. Cunningham,David J. Elliott +21 more
TL;DR: It is found thatSLM2 levels are maintained by a homeostatic feedback control pathway that predates the divergence of SLM2 and Sam68, and Cortical neural network activity dependent on synaptic connections between SLM1-expressing-pyramidal neurons and interneurons is decreased in Slm2-null mice.
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Peritumoral epilepsy: Relating form and function for surgical success
TL;DR: This review discusses key candidates that may be implicated in peritumoral epileptogenesis, the current role of antiepileptic medications in this type of epilepsy and examines the changes in surgical practice which may lead to improved seizure rates after tumor surgery.
Journal ArticleDOI
Human and rodent temporal lobe epilepsy is characterized by changes in O-GlcNAc homeostasis that can be reversed to dampen epileptiform activity.
Richard G. Sanchez,R. Ryley Parrish,Megan Rich,William M. Webb,Roxanne M Lockhart,Kazuhito Nakao,Lara Ianov,Susan C. Buckingham,Devin R. Broadwater,Alistair Jenkins,Nihal C. de Lanerolle,Mark O. Cunningham,Tore Eid,Kristen O. Riley,Farah D. Lubin +14 more
TL;DR: Inhibiting OGA with Thiamet-G elevated protein O-GlcNAcylation, and decreased both seizure duration and epileptic spike events, suggesting that OGA may be a therapeutic target for seizure control.
Journal ArticleDOI
Dendrotoxin sensitive potassium channels modulate GABA but not glutamate release in the rat entorhinal cortex in vitro.
TL;DR: It is concluded that K-channels containing the Kv1.2 and/or 1.6 subunits modulate the release of GABA, but not glutamate in the entorhinal cortex, because the modulation of GABA release by phenytoin is unlikely to be due to an effect on these channels.
Journal ArticleDOI
Cannabis and epilepsy.
TL;DR: This podcast addresses what an adult neurologist needs to know now, ahead of the likely licensing of Epidiolex in the UK in 2019, and the difference between artisanal cannabidiol products available legally on the high street and the cannabids that have strong trial evidence.