M
Mark O. Cunningham
Researcher at Newcastle University
Publications - 82
Citations - 5297
Mark O. Cunningham is an academic researcher from Newcastle University. The author has contributed to research in topics: Kainate receptor & Entorhinal cortex. The author has an hindex of 36, co-authored 77 publications receiving 4774 citations. Previous affiliations of Mark O. Cunningham include University of Leeds & University of Newcastle.
Papers
More filters
Journal ArticleDOI
Mitochondria and cortical gamma oscillations: food for thought?
TL;DR: Increasingly, modalities such as functional MRI and positron emission tomography are finding their place in clinical neurological practice and provide useful information concerning both physiological and pathophysiological modes of operation in particular regions of the brain.
Posted ContentDOI
Human and Rodent Temporal Lobe Epilepsy is Characterized by Changes in O-GlcNAc Homeostasis that can be Reversed to Dampen Epileptiform Activity
Richard G. Sanchez,R. Ryley Parrish,Megan Rich,William M. Webb,Roxanne M Lockhart,Kazuhito Nakao,Lara Ianov,Susan C. Buckingham,Mark O. Cunningham,Devin R. Broadwater,Alistair Jenkins,Nihal C. de Lanerolle,Tore Eid,Kristen O. Riley,Farah D. Lubin +14 more
TL;DR: Inhibiting OGA with Thiamet-G elevated protein O-GlcNAcylation, and decreased both seizure duration and epileptic spike events, suggesting that OGA may be a therapeutic target for seizure control.
Journal ArticleDOI
MicroRNA inhibition using antimiRs in acute human brain tissue sections
Gareth Morris,Elena Langa,Conor Fearon,Karen Conboy,Kelvin Lau E-How,Amaya Sanz-Rodriguez,Donncha F. O’Brien,Kieron J. Sweeney,A. Lacey,Norman Delanty,Alan Beausang,Francesca Brett,Jane Cryan,Mark O. Cunningham,David C. Henshall +14 more
TL;DR: In this article , the authors developed an antimiR testing platform in human brain tissue sections, which was used for pre-clinical testing of antimiRs targeting microRNA-134 (antimiR-134).
Posted ContentDOI
Closed-loop optogenetic control of normal and pathological network dynamics
Boubker Zaaimi,Mark Turnbull,Anupam Hazra,Yujiang Wang,Carolina Gandara de Souza,Enrique Escobedo-Cousin,Ahmad Shah Idil,Richard G. Bailey,Sabrina Tardio,Aaliyah Patel,Nikhil K. Ponon,Frances Hutchings,Marcus Kaiser,Mark O. Cunningham,Gavin J. Clowry,Fiona E. N. LeBeau,Timothy G. Constandinou,Stuart N. Baker,Nick Donaldson,Patrick Degenaar,Anthony O'Neill,Andrew J. Trevelyan,Andrew Jackson +22 more
TL;DR: Closed-loop optogenetic stimulation with excitatory opsins (CLOSe) affords precise manipulation of neural dynamics, both in vitro, in brain slices from transgenic mice, and in vivo, with anesthetised monkeys, paving the way for translation of closed- loop optogenetics towards therapeutic applications in humans.