Showing papers in "Epilepsy & Behavior in 2014"

TL;DR: This critical review summarizes known risks associated with refractory epilepsy, provides practical clinical recommendations, and indicates areas for future research.

TL;DR: An overview of seizure detection and related prediction methods is presented and their potential uses in closed-loop warning systems in epilepsy are discussed.

TL;DR: Evidence indicates that early-life stress can induce persistent changes in the ability of the HPA axis to respond to stress in adulthood, and these abnormalities appear to be related to changes inThe ability of hormones to bind to GR and MR receptors.

TL;DR: The findings suggest that the left claustrum/anterior insula is an important part of a network that subserves consciousness and that disruption of consciousness is related to increased EEG signal synchrony within frontal-parietal networks.

TL;DR: The scientific data support the role of the endocannabinoid system in seizure generation, maintenance, and control in animal models of epilepsy and there are clear data for the negative effects of cannabis on the developing and mature brain though these effects appear to be relatively mild in most cases.

TL;DR: Children with uncontrolled epilepsy use significantly more healthcare resources and have a greater economic burden than children with stable epilepsy, indicating that comorbid conditions may add substantially to the disease burden.

TL;DR: The GAD-7 is a reliable and valid screening tool for detecting GAD in PWE and its differential effect from adverse effects of antiepileptic drugs (AEDs) on the detection of anxiety in Korean PWE is examined.

TL;DR: Depression as measured by the NDDI-E was correlated with an increased risk of AED nonadherence and depression or seizure severity adversely impacted QOL, demonstrating yet another important reason to screen for depression in epilepsy.

TL;DR: The findings may have implications for the better management of epilepsy by increasing a focus on nonpharmacological therapy and the implications for nosology and causation of epilepsy are briefly discussed.

TL;DR: St salient, adherence-related beliefs about AEDs were identified and patient-centered interventions to support medicine optimization for people with epilepsy should take account of these beliefs.

TL;DR: The mechanisms underlying the emergence of consciousness after severe brain injury are not thoroughly understood and important questions remain unanswered: What triggers the connectivity impairment leading to disorders of consciousness?

TL;DR: Advances made in NSC grafting therapy for treating hippocampal injury in animal models of excitotoxic injury, traumatic brain injury, Alzheimer's disease, and status epilepticus are presented; potential mechanisms of functional recovery mediated by N SC grafts placed early after hippocampusal injury; and issues that need to be resolved are presented.

TL;DR: The psychometric properties of the Neurological Disorders Depression Inventory for Epilepsy, Hospital Anxiety and Depression Scale Depression Subscale, and Beck Depression Inventory as screening instruments for depression and suicidality in people with epilepsy have been evaluated.

TL;DR: Perceived negative reactions to SUDEP discussions are common but not universal; more experienced neurologists may be less likely to encounter negative reactions, suggesting that there may be ways to frame the discussion that minimizes patient/caregiver distress.

TL;DR: The role of cytokines in hippocampal physiological processes, such as memory and learning, and the pathological involvement of cytokine in diseases like depression and epilepsy are focused on.

TL;DR: After 12 months of transcutaneous vagus nerve stimulation in patients with pharmacoresistant epilepsy, the monthly seizure frequency was lower in the treatment group than in the control group (8.0 to 4.0; P=0.003), which was correlated with seizure frequency at baseline and duration of epilepsy.

TL;DR: It is found that quality of life, depressive symptoms, and social support have the greatest impact on reported felt stigma in individuals with prevalent epilepsy.

TL;DR: There are complex relationships among social determinants of health in epilepsy, which remain poorly understood and hamper efforts to address and eliminate disparities in epilepsy care and outcomes.

TL;DR: The results suggest that it is possible that SWDs occur in rodent models of TLE and that investigators mistakenly assume that they are stage 1-2 limbic seizures.

TL;DR: The PHQ-9 is an efficient and nonproprietary depression screening instrument with excellent accuracy validated for use in adult patients with epilepsy as well as multiple other medical populations.

TL;DR: The role of implicit anxiety is demonstrated in PNESs and additional support for the contribution of explicit anxiety and experiential avoidance to this disorder is provided.

TL;DR: Studying the relation between anatomo-electro-clinical correlations of stereoelectroencephalography (SEEG) data indicate that the clinical semiology of a given seizure depends upon neither the anatomical origin of ictal discharge nor the target areas of its propagation alone but on the dynamic interaction between these.

TL;DR: An overview of the effects of stress on the brain is provided and human as well as preclinical studies evaluating the relation between stress, epileptic seizures, and epileptogenesis are discussed, focusing on the epileptogenic effects of early life stress.

TL;DR: The results support the executive dysfunction hypothesis in daily life of children with structural focal epilepsy or focal epilepsy of unknown cause and are consistent with the early brain vulnerability hypothesis currently prevalent in the context of child neuropsychology.

TL;DR: Data is summarized on the relationship between neurocardiac genes that may contribute to a genetic susceptibility for SUDEP, discussing their brain-heart expression patterns and genotype-phenotype correlations in mouse models and people with epilepsy.

TL;DR: It is proposed that PNES behaviors and experiences of reduced control or awareness may also represent direct behavioral manifestation of overwhelming emotions, or that minor emotional fluctuations or relatively neutral stimuli may trigger PNESs through conditioning or other preconscious processes.

TL;DR: The intrarater and interrater reliability of EEG interpretation has significant implications for the value of EEG as a diagnostic tool and an automated online application integrated into a continuing medical education module that measures and reports EEG I&IR to individual users is proposed.

TL;DR: It is concluded that normal MRI results should not preclude presurgical evaluations in patients with medically refractory TLE, as favorable long-term postoperative seizure outcomes are possible, especially in Patients with unilateral anterior interictal epileptiform discharges and ipsilateral temporal PET hypometabolism.

TL;DR: Granule cell abnormalities in temporal lobe epilepsy appear to be phenocopies of granule cell deficits produced by genetic mouse models of autism and schizophrenia, suggesting that granules cell dysmorphogenesis may be a common factor uniting these seemingly diverse diseases.

TL;DR: The majority of the panic attack symptoms including heart palpitations, sweating, shortness of breath, choking feeling, chest discomfort, dizziness/unsteadiness, derealization or depersonalization, fear of dying, paresthesias, and chills or hot flashes were significantly more frequent in those with PNES.