M
Mark R. Pelletier
Researcher at Washington University in St. Louis
Publications - 3
Citations - 645
Mark R. Pelletier is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Promoter & Gene. The author has an hindex of 3, co-authored 3 publications receiving 628 citations.
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Journal ArticleDOI
Stat1 depends on transcriptional synergy with Sp1.
TL;DR: Assays of DNA/protein binding and activity of transfected reporter plasmids determined that occupation of contiguous DNA-binding sites for Stat1 (the first member of the STAT family) and the transcriptional activator Sp1 are both required for full activation of the intercellular adhesion molecule-1 gene by interferon - thus, Stat1 binding to DNA cannot by itself be equated with biologic actions of Stat1.
Journal ArticleDOI
Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals
Jeffrey W. Tyner,Edy Y. Kim,Kyotaro Ide,Mark R. Pelletier,William T. Roswit,Jeffrey D. Morton,John T. Battaile,Anand C. Patel,G. Alexander Patterson,Mario Castro,Melanie S. Spoor,Yingjian You,Steven L. Brody,Michael J. Holtzman +13 more
TL;DR: It is shown that long-term ciliated cell hyperplasia coincides with mucous (goblet) cell metaplasia after respiratory viral clearance in mouse airways, and the distinct effects of EGFR and IL-13 inhibitors after viral reprogramming suggest that these combined therapeutic strategies may also correct epithelial architecture in the setting of airway inflammatory disorders.
Journal ArticleDOI
Selective interaction of a subset of interferon-gamma response element-binding proteins with the intercellular adhesion molecule-1 (ICAM-1) gene promoter controls the pattern of expression on epithelial cells.
TL;DR: Evidence is provided for a distinct IRE subset that combines a DNA element common to all IFN-responsive genes (GAAA) with a distinct flanking sequence (the inverted repeat GAAA) in order to fine-tune IFN responses and activate a subset of immune response genes (ICAM-1, Fc gamma RI, and IRF-1).