M
Michael J. Holtzman
Researcher at Washington University in St. Louis
Publications - 247
Citations - 19500
Michael J. Holtzman is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 73, co-authored 232 publications receiving 16483 citations. Previous affiliations of Michael J. Holtzman include University of Washington.
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Journal ArticleDOI
Potently neutralizing and protective human antibodies against SARS-CoV-2.
Seth J. Zost,Pavlo Gilchuk,James Brett Case,Elad Binshtein,Rita E. Chen,Joseph P. Nkolola,Alexandra Schäfer,Joseph X. Reidy,Andrew Trivette,Rachel S. Nargi,Rachel E. Sutton,Naveenchandra Suryadevara,David R. Martinez,Lauren E. Williamson,Elaine C. Chen,Taylor Jones,Samuel Day,Luke Myers,Ahmed O. Hassan,Natasha M. Kafai,Emma S. Winkler,Julie M. Fox,Swathi Shrihari,Benjamin K. Mueller,Jens Meiler,Jens Meiler,Abishek Chandrashekar,Noe B. Mercado,James J. Steinhardt,Kuishu Ren,Yueh-Ming Loo,Nicole L. Kallewaard,Broc T. McCune,Shamus P. Keeler,Michael J. Holtzman,Dan H. Barouch,Lisa E. Gralinski,Ralph S. Baric,Larissa B. Thackray,Michael S. Diamond,Robert H. Carnahan,James E. Crowe +41 more
TL;DR: An analysis identifies human monoclonal antibodies that potently neutralize wild-type SARS-CoV-2 and protect animals from disease, including two that synergize in a cocktail, suggesting that these could be candidates for use as therapeutic agents for the treatment of COVID-19 in humans.
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Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells
Brian T. Edelson,Wumesh Kc,Richard Juang,Masako Kohyama,Loralyn A. Benoit,Paul A. Klekotka,Clara Moon,Jörn C. Albring,Wataru Ise,Drew G. Michael,Deepta Bhattacharya,Thaddeus S. Stappenbeck,Michael J. Holtzman,Sun-Sang J. Sung,Theresa L. Murphy,Kai Hildner,Kenneth M. Murphy +16 more
TL;DR: Evidence is provided for a developmental relationship between lymphoid organ–resident CD8α+ cDCs and nonlymphoid CD103+ DCs and their shared developmental dependence on the transcription factor Irf8.
Journal ArticleDOI
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.
Emma S. Winkler,Adam L. Bailey,Natasha M. Kafai,Sharmila Nair,Broc T. McCune,Jinsheng Yu,Julie M. Fox,Rita E. Chen,James T. Earnest,Shamus P. Keeler,Jon H. Ritter,Liang I. Kang,Sarah Dort,Annette Robichaud,Richard D. Head,Michael J. Holtzman,Michael S. Diamond +16 more
TL;DR: The transgenic mice expressing the human angiotensin I-converting enzyme 2 (ACE2) receptor driven by the cytokeratin-18 (K18) gene promoter are evaluated as a model of SARS-CoV-2 infection to define the basis of lung disease and test immune and antiviral-based countermeasures.
Journal ArticleDOI
Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease.
Edy Y. Kim,John T. Battaile,Anand C. Patel,Yingjian You,Eugene Agapov,Mitchell H. Grayson,Loralyn A. Benoit,Derek E. Byers,Yael G. Alevy,Jennifer Tucker,Suzanne Swanson,Rose M. Tidwell,Jeffrey W. Tyner,Jeffrey D. Morton,Mario Castro,Deepika Polineni,G. Alexander Patterson,Reto A. Schwendener,John Allard,Gary Peltz,Michael J. Holtzman +20 more
TL;DR: It is found that this type of disease arises independently of an adaptive immune response and is driven instead by interleukin-13 produced by macrophages that have been stimulated by CD1d-dependent T cell receptor–invariant natural killer T (NKT) cells.
Journal ArticleDOI
A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies.
Ahmed O. Hassan,James Brett Case,Emma S. Winkler,Larissa B. Thackray,Natasha M. Kafai,Adam L. Bailey,Broc T. McCune,Julie M. Fox,Rita E. Chen,Wafaa B. Alsoussi,Jackson S. Turner,Aaron J. Schmitz,Tingting Lei,Swathi Shrihari,Shamus P. Keeler,Daved H. Fremont,Suellen Greco,Paul B. McCray,Stanley Perlman,Michael J. Holtzman,Ali H. Ellebedy,Michael S. Diamond +21 more
TL;DR: Transduced replication-defective adenoviruses encoding human ACE2 via intranasal administration into BALB/c mice and established receptor expression in lung tissues and passive transfer of a neutralizing monoclonal antibody reduced viral burden in the lung and mitigated inflammation and weight loss.