J
John T. Battaile
Researcher at University of Texas Southwestern Medical Center
Publications - 22
Citations - 1895
John T. Battaile is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Lung & Innate immune system. The author has an hindex of 12, co-authored 22 publications receiving 1718 citations. Previous affiliations of John T. Battaile include Washington University in St. Louis & National Institutes of Health.
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Journal ArticleDOI
Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease.
Edy Y. Kim,John T. Battaile,Anand C. Patel,Yingjian You,Eugene Agapov,Mitchell H. Grayson,Loralyn A. Benoit,Derek E. Byers,Yael G. Alevy,Jennifer Tucker,Suzanne Swanson,Rose M. Tidwell,Jeffrey W. Tyner,Jeffrey D. Morton,Mario Castro,Deepika Polineni,G. Alexander Patterson,Reto A. Schwendener,John Allard,Gary Peltz,Michael J. Holtzman +20 more
TL;DR: It is found that this type of disease arises independently of an adaptive immune response and is driven instead by interleukin-13 produced by macrophages that have been stimulated by CD1d-dependent T cell receptor–invariant natural killer T (NKT) cells.
Journal ArticleDOI
Influenza Virus Receptor Specificity and Cell Tropism in Mouse and Human Airway Epithelial Cells
Aida Ibricevic,Andrew Pekosz,Michael J. Walter,Celeste M. Newby,John T. Battaile,Earl G. Brown,Michael J. Holtzman,Steven L. Brody +7 more
TL;DR: Differences in receptor and cell-specific expression in these species suggest that differentiated human airway epithelial cell cultures may be superior for evaluation of some human strains, while the mouse can provide a model for studying avian strains that preferentially bind only the α2,3-linked SA receptor.
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Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals
Jeffrey W. Tyner,Edy Y. Kim,Kyotaro Ide,Mark R. Pelletier,William T. Roswit,Jeffrey D. Morton,John T. Battaile,Anand C. Patel,G. Alexander Patterson,Mario Castro,Melanie S. Spoor,Yingjian You,Steven L. Brody,Michael J. Holtzman +13 more
TL;DR: It is shown that long-term ciliated cell hyperplasia coincides with mucous (goblet) cell metaplasia after respiratory viral clearance in mouse airways, and the distinct effects of EGFR and IL-13 inhibitors after viral reprogramming suggest that these combined therapeutic strategies may also correct epithelial architecture in the setting of airway inflammatory disorders.
Journal ArticleDOI
Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia.
Mitchell H. Grayson,Dorothy S. Cheung,M.M. Rohlfing,R.T. Kitchens,Daniel E. Spiegel,Jennifer Tucker,John T. Battaile,Yael G. Alevy,Le Yan,Eugene Agapov,Edy Y. Kim,Michael J. Holtzman +11 more
TL;DR: Lung DC expression of FcεRIα is part of the antiviral response that recruits CD4+ T cells and drives mucous cell metaplasia, thus linking antiviral responses to allergic/asthmatic Th2 responses.
Journal ArticleDOI
Pulmonary arteriovenous malformations: diagnosis.
Sachin S. Saboo,Murthy R. Chamarthy,Sanjeev Bhalla,Harold Park,Patrick D. Sutphin,Fernando Uliana Kay,John T. Battaile,Sanjeeva P. Kalva +7 more
TL;DR: Long term clinical and imaging follow-up is required to assess PAVM enlargement and PAVM reperfusion, and CT has become the gold standard imaging test to establish the presence of PAVM.