M
Marketa Jirouskova
Researcher at Rockefeller University
Publications - 19
Citations - 1726
Marketa Jirouskova is an academic researcher from Rockefeller University. The author has contributed to research in topics: Platelet & Fibrinogen. The author has an hindex of 13, co-authored 15 publications receiving 1550 citations. Previous affiliations of Marketa Jirouskova include University of Cincinnati Academic Health Center & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell–mediated elimination of tumor cells
Joseph S. Palumbo,Kathryn E. Talmage,Kathryn E. Talmage,Jessica V. Massari,Jessica V. Massari,Christine M. La Jeunesse,Christine M. La Jeunesse,Matthew J. Flick,Matthew J. Flick,Keith W. Kombrinck,Keith W. Kombrinck,Marketa Jirouskova,Marketa Jirouskova,Jay L. Degen,Jay L. Degen +14 more
TL;DR: These studies establish an important link between hemostatic factors and innate immunity and indicate that one mechanism by which the platelet-fibrin(ogen) axis contributes to metastatic potential is by impeding natural killer cell elimination of tumor cells.
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Leukocyte engagement of fibrin(ogen) via the integrin receptor αMβ2/Mac-1 is critical for host inflammatory response in vivo
Matthew J. Flick,Xin Li Du,David P. Witte,Marketa Jirouskova,Dmitry A. Soloviev,Steven J. Busuttil,Edward F. Plow,Jay L. Degen,Jay L. Degen +8 more
TL;DR: These studies definitively demonstrate that fibrin(ogen) is a physiologically relevant ligand for αMβ2, integrin engagement of fibr inogen is critical to leukocyte function and innate immunity in vivo, and the biological importance of fibinogen in regulating the inflammatory response can be appreciated outside of any alteration in clotting function.
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A guide to murine platelet structure, function, assays, and genetic alterations
TL;DR: This review presents general recommendations with respect to collection, isolation and processing of murine platelets and describes the assays currently available to study platelet function and critically assesses their utility.
Journal ArticleDOI
Application of high-throughput screening to identify a novel αIIb-specific small- molecule inhibitor of αIIbβ3-mediated platelet interaction with fibrinogen
TL;DR: Compound 1 provides a prototype for small molecule selective inhibition of αIIbβ3, without receptor priming, via targeting αIIa, and molecular docking simulations suggest that compound 1 interacts with αiib but not β3.
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Dynamics of GPIIb/IIIa-mediated platelet-platelet interactions in platelet adhesion/thrombus formation on collagen in vitro as revealed by videomicroscopy
Dipti Patel,Heikki Väänänen,Heikki Väänänen,Marketa Jirouskova,Marketa Jirouskova,Thomas J. Hoffmann,Thomas J. Hoffmann,Carol A. Bodian,Carol A. Bodian,Barry S. Coller,Barry S. Coller +10 more
TL;DR: In this model system, absence or blockade of GPIIb/IIIa receptors interferes with thrombus formation and alters the pattern of platelet deposition, resulting in a more uniform deposition than predicted.