Journal ArticleDOI
Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell–mediated elimination of tumor cells
Joseph S. Palumbo,Kathryn E. Talmage,Kathryn E. Talmage,Jessica V. Massari,Jessica V. Massari,Christine M. La Jeunesse,Christine M. La Jeunesse,Matthew J. Flick,Matthew J. Flick,Keith W. Kombrinck,Keith W. Kombrinck,Marketa Jirouskova,Marketa Jirouskova,Jay L. Degen,Jay L. Degen +14 more
TLDR
These studies establish an important link between hemostatic factors and innate immunity and indicate that one mechanism by which the platelet-fibrin(ogen) axis contributes to metastatic potential is by impeding natural killer cell elimination of tumor cells.About:
This article is published in Blood.The article was published on 2005-01-01. It has received 838 citations till now. The article focuses on the topics: Lymphokine-activated killer cell & Platelet activation.read more
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Microenvironmental regulation of tumor progression and metastasis.
TL;DR: The paradoxical roles of the tumor microenvironment during specific stages of cancer progression and metastasis are discussed, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects.
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Emerging Biological Principles of Metastasis
TL;DR: The cellular and molecular mechanisms involved in metastasis are summarized, with a focus on carcinomas where the most is known, and the general principles of metastasis that have begun to emerge are highlighted.
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Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis
TL;DR: It is shown that platelet-tumor cell interactions are sufficient to prime tumor cells for subsequent metastasis and inhibit NF-κB signaling in cancer cells, resulting in their transition to an invasive mesenchymal-like phenotype and enhanced metastasis in vivo.
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Contribution of platelets to tumour metastasis.
TL;DR: Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.
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The sweet and sour of cancer: glycans as novel therapeutic targets.
Mark M. Fuster,Jeffrey D. Esko +1 more
TL;DR: A growing body of evidence supports crucial roles for glycans at various pathophysiological steps of tumour progression, and increased understanding of these roles sets the stage for developing pharmaceutical agents that target these molecules.
References
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Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
TL;DR: Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.
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Aspirin use and reduced risk of fatal colon cancer
TL;DR: Regular aspirin use at low doses may reduce the risk of fatal colon cancer in people who used aspirin 16 or more times per month for at least one year.
Journal Article
Protocols for screening chemical agents and natural products against animal tumors and other biological systems
Journal Article
Lysis of Tumor Cells by Natural Killer Cells in Mice Is Impeded by Platelets
TL;DR: It is demonstrated for the first time that platelets directly protect tumor cells from NK lysis in vitro as well as in vivo, thereby promoting metastasis and surface shielding by platelet aggregates seems to be the main mechanism.
Journal ArticleDOI
Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development.
Ramesh A. Shivdasani,Margery Rosenblatt,Dorothea Zucker-Franklin,Carl W. Jackson,Pamela Hunt,Chris J.M Saris,Stuart H. Orkin +6 more
TL;DR: The authors showed that NF-E2 −/− mice lack circulating platelets and die of hemorrhage; their megakaryocytes show no cytoplasmic platelet formation.