M
Markus Grompe
Researcher at Oregon Health & Science University
Publications - 323
Citations - 37404
Markus Grompe is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Fanconi anemia & Stem cell. The author has an hindex of 88, co-authored 313 publications receiving 34220 citations. Previous affiliations of Markus Grompe include Northwestern University & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
AAV-mediated gene targeting is significantly enhanced by transient inhibition of nonhomologous end joining or the proteasome in vivo.
TL;DR: The benefit of transient NHEJ inhibition with vanillin, or proteasome blockage with bortezomib, for increasing hepatic gene targeting with rAAV is established and evidence for the feasibility of gene targeting as a therapeutic strategy is provided.
Journal ArticleDOI
Therapeutic Liver Reconstitution With Murine Cells Isolated Long After Death
Laura R Erker,Hisaya Azuma,Andrew Y. Lee,Changsheng Guo,Susan L. Orloff,Laura Eaton,Eric Benedetti,Bryan E. Jensen,Milton J. Finegold,Holger Willenbring,Markus Grompe +10 more
TL;DR: Surprisingly, complete and therapeutic liver repopulation could be achieved with hepatocytes derived up to 27 hours post mortem, and non-heart-beating donors could be a suitable source of hepatocytes for much longer time periods than previously thought possible.
Journal ArticleDOI
Adult versus embryonic stem cells: It's still a tie
TL;DR: MAPCs contributed to virtually all tissues, including the brain, retina, lung, skeletal mus-cle, myocardium, liver, intestine, kidney, skin, spleen, and blood, although only 1 !
Book ChapterDOI
Fah Knockout Animals as Models for Therapeutic Liver Repopulation.
TL;DR: The potent expansion of human hepatocytes in Fah knockout mice has given rise to the concept of using Fah mutants as living bioreactors to produce large quantities of fully mature hepatocytes, creating "mice with human livers".
Journal ArticleDOI
Prenatal Diagnosis of Succinic Semialdehyde Dehydrogenase Deficiency: Increased Accuracy Employing DNA, Enzyme, and Metabolite Analyses
Boris M. Hogema,Boris M. Hogema,Boris M. Hogema,Shinjiro Akaboshi,Matthew H. Taylor,Gajja S. Salomons,C. Jakobs,Ruud B.H. Schutgens,Bridget Wilcken,S. Worthington,G. Maropoulos,Markus Grompe,K. M. Gibson +12 more
TL;DR: The data demonstrate the importance of combined metabolite, enzyme, and DNA analysis for increased accuracy in the PND of SSADH deficiency, and hypothesize that delayed transit time for shipment of CV between Greece and the United States (8 days) led to enhanced degradation of heterozygousSSADH enzyme activity.