M
Markus Grompe
Researcher at Oregon Health & Science University
Publications - 323
Citations - 37404
Markus Grompe is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Fanconi anemia & Stem cell. The author has an hindex of 88, co-authored 313 publications receiving 34220 citations. Previous affiliations of Markus Grompe include Northwestern University & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Tempol Protects against Oxidative Damage and Delays Epithelial Tumor Onset in Fanconi Anemia Mice
Qing Shuo Zhang,Laura Eaton,Eric R. Snyder,Scott Houghtaling,James B. Mitchell,Milton J. Finegold,Carter Van Waes,Markus Grompe +7 more
TL;DR: Results show that tempol can significantly delay tumor formation in Fancd2(-/-) Trp53(+/-) mice, and the reduction in oxidative DNA damage in tempol-treated FA fibroblasts and mice suggests that its tumor-delaying function may be attributed to its antioxidant activity.
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The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar.
Craig Dorrell,Branden D. Tarlow,Yuhan Wang,Pamela S. Canaday,Annelise Haft,Jonathan Schug,Philip R. Streeter,Milton J. Finegold,Lincoln T. Shenje,Klaus H. Kaestner,Markus Grompe +10 more
TL;DR: Surprisingly, pancreatic organoid cells also had the capacity to generate hepatocyte-like cells upon transplantation to Fah(-/-) mice, indicating a differentiation capacity similar to hepatic organoids.
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Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure
Sandra Torres,Anna Baulies,Naroa Insausti-Urkia,Cristina Alarcón-Vila,Raquel Fucho,Estel Solsona-Vilarrasa,Susana Nuñez,David Robles,Vicent Ribas,Leslie Wakefield,Markus Grompe,M. Isabel Lucena,Raúl J. Andrade,Sanda Win,Tin A. Aung,Neil Kaplowitz,Carmen García-Ruiz,Carmen García-Ruiz,José C. Fernández-Checa,José C. Fernández-Checa +19 more
TL;DR: It is found that upregulation of STARD1 following ER stress mediates acetaminophen hepatoxicity via SH3BP5 and phosphorylation of JNK1 and JNK2 and is observed in FRGN mice with humanized liver.
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Fanconi anemia group A and C double-mutant mice: functional evidence for a multi-protein Fanconi anemia complex.
Meenakshi Noll,Kevin P. Battaile,Raynard L. Bateman,Timothy Lax,Keany Rathbun,Carol Reifsteck,Grover C. Bagby,Milton J. Finegold,Susan B. Olson,Markus Grompe +9 more
TL;DR: In this paper, the authors show that the FA group A and group C genes have identical or partially distinct functions and have a better model for human FA than those of FA group B and C genes.
Journal ArticleDOI
Liver repopulation for the treatment of metabolic diseases
TL;DR: It has been discovered that transplanted cells from extrahepatic sources such as the adult pancreas or bone marrow can also be used for liver repopulation, and this finding raises the hope of therapeutic application of these cells in the future.