M
Markus Grompe
Researcher at Oregon Health & Science University
Publications - 323
Citations - 37404
Markus Grompe is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Fanconi anemia & Stem cell. The author has an hindex of 88, co-authored 313 publications receiving 34220 citations. Previous affiliations of Markus Grompe include Northwestern University & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Gene therapy of metachromatic leukodystrophy reverses neurological damage and deficits in mice
Alessandra Biffi,Alessia Capotondo,Stefania Fasano,Ubaldo Del Carro,Sergio Marchesini,Hisaya Azuma,Maria Chiara Malaguti,Stefano Amadio,Riccardo Brambilla,Markus Grompe,Claudio Bordignon,Angelo Quattrini,Luigi Naldini +12 more
TL;DR: Results indicate that the recruitment of gene-modified, enzyme-overexpressing microglia makes the enzyme bioavailable to the brain and makes therapeutic efficacy and disease correction attainable.
Journal ArticleDOI
Molecular biology of Fanconi anemia: implications for diagnosis and therapy.
Alan D. D'Andrea,Markus Grompe +1 more
TL;DR: FANCONI ANEMIA (FA) is a rare autosomal recessive disease characterized by multiple congenital abnormalities, bone marrow failure, and cancer susceptibility.
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Transcriptomes of the major human pancreatic cell types
Craig Dorrell,Jonathan Schug,Chiao-Feng Lin,Pamela S. Canaday,Alan J. Fox,Olga Smirnova,Robert A. Bonnah,Philip R. Streeter,Christian J. Stoeckert,Klaus H. Kaestner,Markus Grompe +10 more
TL;DR: Analysis of the transcriptomes of human exocrine and endocrine pancreatic cell types revealed previously unrecognised gene expression patterns in these cell types, including transcriptional regulators HOPX and HDAC9 in the human beta cell population.
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Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function
H. Efsun Arda,Lingyu Li,Jennifer Tsai,Eduardo A. Torre,Yenny R. Rosli,Heshan Peiris,Robert C. Spitale,Chunhua Dai,Xueying Gu,Kun Qu,Pei Wang,Jing Wang,Markus Grompe,Raphael Scharfmann,Michael Snyder,Rita Bottino,Alvin C. Powers,Alvin C. Powers,Alvin C. Powers,Howard Y. Chang,Seung K. Kim +20 more
TL;DR: This work describes a multimodal strategy for isolating pancreatic endocrine and exocrine cells from children and adults to identify age-dependent gene expression and chromatin changes on a genomic scale and provides a unique resource to study human-specific regulators of islet cell maturation and function.
Journal ArticleDOI
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway
Patrick Viatour,Ursula Ehmer,Louis A. Saddic,Craig Dorrell,Jesper B. Andersen,Chenwei Lin,Anne Flore Zmoos,Pawel K. Mazur,Bethany E. Schaffer,Austin Ostermeier,Hannes Vogel,Karl G. Sylvester,Snorri S. Thorgeirsson,Markus Grompe,Julien Sage +14 more
TL;DR: Mice lacking all three Rb genes in the liver develop tumors resembling specific subgroups of human hepatocellular carcinomas, and Notch activity appears to suppress the growth and progression of these tumors.