M
Markus Grompe
Researcher at Oregon Health & Science University
Publications - 323
Citations - 37404
Markus Grompe is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Fanconi anemia & Stem cell. The author has an hindex of 88, co-authored 313 publications receiving 34220 citations. Previous affiliations of Markus Grompe include Northwestern University & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Positional Cloning of a Novel Fanconi Anemia Gene, FANCD2
Cynthia Timmers,Toshiyasu Taniguchi,James Hejna,Carol Reifsteck,Lora Lucas,Donald A. Bruun,Matthew J. Thayer,Barbara Cox,Susan B. Olson,Alan D. D'Andrea,Robb E. Moses,Markus Grompe +11 more
TL;DR: Fanconi anemia (FA) is a genetic disease with birth defects, bone marrow failure, and cancer susceptibility as discussed by the authors, which is also known as Fanconi Anemia deficiency.
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Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6.
Siniša Volarević,Mary J. Stewart,Birgit Ledermann,Frederic Zilberman,Luigi Terracciano,Eugenio Montini,Markus Grompe,Sara C. Kozma,George Thomas +8 more
TL;DR: Results imply that abrogation of 40S ribosome biogenesis may induce a checkpoint control that prevents cell cycle progression, and imply that ribosomal protein S6 deficient animals deficient in S6 grew in response to nutrients.
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Myelomonocytic cells are sufficient for therapeutic cell fusion in liver.
Holger Willenbring,Alexis S. Bailey,Mark Foster,Yassmine Akkari,Craig Dorrell,Susan B. Olson,Milton J. Finegold,William H. Fleming,Markus Grompe +8 more
TL;DR: These results provide direct evidence that committed myelomonocytic cells such as macrophages can produce functional epithelial cells by in vivo fusion and provide potential for targeted and well-tolerated cell therapy aimed at organ regeneration.
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AAV serotype 2 vectors preferentially integrate into active genes in mice
TL;DR: This is the first report to the authors' knowledge on host chromosomal effects of rAAV2 integration in animals, and it provides insights into the nature of r AAV2 vector integration into chromosomes in quiescent somatic cells in animals and human subjects.
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Epigenomic plasticity enables human pancreatic α to β cell reprogramming
Nuria C. Bramswig,Logan J. Everett,Jonathan Schug,Craig Dorrell,Chengyang Liu,Yanping Luo,Philip R. Streeter,Ali Naji,Markus Grompe,Klaus H. Kaestner +9 more
TL;DR: M mammalian pancreatic islet cells display cell-type-specific epigenomic plasticity, suggesting that epigenomic manipulation could provide a path to cell reprogramming and novel cell replacement-based therapies for diabetes.