M
Markus Haug
Researcher at Norwegian University of Science and Technology
Publications - 31
Citations - 856
Markus Haug is an academic researcher from Norwegian University of Science and Technology. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 13, co-authored 30 publications receiving 618 citations. Previous affiliations of Markus Haug include University of Tübingen & Central Norway Regional Health Authority.
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Journal ArticleDOI
Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection
Kai Sandvold Beckwith,Marianne Sandvold Beckwith,Sindre Ullmann,Ragnhild Sofie Ragnhildstveit Sætra,Haelin Kim,Anne Marstad,Signe Elisabeth Åsberg,Trine Aakvik Strand,Markus Haug,Michael Niederweis,Harald Stenmark,Harald Stenmark,Trude Helen Flo +12 more
TL;DR: Live single-cell imaging is used to show two mechanisms by which M. tuberculosis causes damage to human macrophage cell plasma membranes, resulting in activation of the NLRP3 inflammasome, pyroptosis and release of infectious particles.
Journal ArticleDOI
Impaired suppression of synovial fluid CD4+CD25- T cells from patients with juvenile idiopathic arthritis by CD4+CD25+ Treg cells.
Susanne Haufe,Markus Haug,Carsten P. Schepp,Jasmin B Kuemmerle-Deschner,Sandra Hansmann,Nikolaus Rieber,Nikolay Tzaribachev,Toni Hospach,Jan Maier,Guenther E. Dannecker,Ursula Holzer +10 more
TL;DR: The findings indicate that regulation is impaired in the SF of patients with JIA, as shown by the resistance of effector T cells to immunoregulation by functional Treg cells.
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The intercell dynamics of T cells and dendritic cells in a lymph node-on-a-chip flow device
TL;DR: This microphysiological model provides new possibilities to recreate a controlled mechanical force threshold of pMHC-TCR binding, allowing the investigation of intercellular signalling of immune synapses and therapeutic targets for immunotherapy.
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Intracellular Mycobacterium avium Intersect Transferrin in the Rab11+ Recycling Endocytic Pathway and Avoid Lipocalin 2 Trafficking to the Lysosomal Pathway
Øyvind Halaas,Magnus Steigedal,Markus Haug,Jane Atesoh Awuh,Liv Ryan,Andreas Brech,Shintaro Sato,Harald Husebye,Gerard A. Cangelosi,Shizuo Akira,Roland K. Strong,Terje Espevik,Trude Helen Flo +12 more
TL;DR: It is shown that Lcn2 suppressed growth of Mycobacterium avium in culture, and M. avium induced LCN2 production from mouse macrophages, suggesting that mycobacteria seem to reside in the Rab11(+) endocytic recycling pathway, thereby retaining access to nutrition and avoiding endocytosed immunoproteins like Lcn1.
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The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells.
Markus Haug,Luciana Dannecker,Carsten P. Schepp,William W. Kwok,Dorothee Wernet,Jane H. Buckner,Hubert Kalbacher,Guenther E. Dannecker,Ursula Holzer +8 more
TL;DR: The potential of Hsp70 is shown to enhance antigen‐specific CD4+ T cell proliferation and to increase the immunogenicity of presented peptides in human CD4-T cells.