H
Harald Husebye
Researcher at Norwegian University of Science and Technology
Publications - 29
Citations - 1898
Harald Husebye is an academic researcher from Norwegian University of Science and Technology. The author has contributed to research in topics: TLR4 & Endosome. The author has an hindex of 18, co-authored 29 publications receiving 1767 citations. Previous affiliations of Harald Husebye include Central Norway Regional Health Authority.
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Journal ArticleDOI
Endocytic pathways regulate Toll‐like receptor 4 signaling and link innate and adaptive immunity
Harald Husebye,Øyvind Halaas,Harald Stenmark,Harald Stenmark,Gro Tunheim,Øystein Sandanger,Bjarne Bogen,Andreas Brech,Eicke Latz,Terje Espevik +9 more
TL;DR: The results show that endosomal trafficking of the LPS receptor complex is essential for signal termination and LPS‐associated antigen presentation, thus controlling both innate and adaptive immunity through TLR4.
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The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes
Harald Husebye,Marie Hjelmseth Aune,Jørgen Stenvik,Eivind O. Samstad,Frode Miltzow Skjeldal,Øyvind Halaas,Nadra J. Nilsen,Harald Stenmark,Harald Stenmark,Eicke Latz,Eicke Latz,Egil Lien,Egil Lien,Tom Eirik Mollnes,Oddmund Bakke,Oddmund Bakke,Terje Espevik +16 more
TL;DR: Rab11a is an important regulator of TLR4 and TRAM transport to E. coli phagosomes thereby controlling IRF3 activation from this compartment and reducing the amount of TRAM on phagosome.
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Guard cell- and phloem idioblast-specific expression of thioglucoside glucohydrolase 1 (myrosinase) in Arabidopsis.
TL;DR: The results suggest a cellular separation of myrosinase enzyme and glucosinolate substrate, and that myrosInase is contained in distinct cells, and the potential advantages of locating defense and communication systems to only a few specific cell types are discussed.
Journal ArticleDOI
TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.
Eva M. Palsson-McDermott,Sarah L. Doyle,Anne F. McGettrick,Matthew P. Hardy,Harald Husebye,Kathy Banahan,Mei Gong,Douglas T. Golenbock,Terje Espevik,Luke A. J. O'Neill +9 more
TL;DR: A splice variant of TRAM, TAG ('TRAM adaptor with GOLD domain'), which has a Golgi dynamics domain coupled to TRAM's Toll–interleukin 1 receptor domain is reported, which could be useful in the effort to boost the immunostimulatory effect of TLR4 without causing unwanted inflammation.
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Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36
Nadra J. Nilsen,Susanne Deininger,Unni Nonstad,Frode Miltzow Skjeldal,Harald Husebye,Dmitrii G. Rodionov,Sonja von Aulock,Thomas Hartung,Egil Lien,Oddmund Bakke,Terje Espevik +10 more
TL;DR: The results suggest that LTA signaling preferentially occurs at the plasma membrane, is independent of internalization, and is facilitated by CD36 and CD14 as coreceptors for TLR2.