M
Markus M. Simon
Researcher at Max Planck Society
Publications - 218
Citations - 9730
Markus M. Simon is an academic researcher from Max Planck Society. The author has contributed to research in topics: Cytotoxic T cell & Borrelia burgdorferi. The author has an hindex of 57, co-authored 217 publications receiving 9388 citations. Previous affiliations of Markus M. Simon include National Institutes of Health.
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Journal ArticleDOI
Lipid A: chemical structure and biological activity.
Otto Lüderitz,Chris Galanos,Volker Lehmann,Marjatta Nurminen,Ernst Th. Rietschel,Günter Rosenfelder,Markus M. Simon,Otto Westphal +7 more
TL;DR: Free lipid A, solubilized by complexing with bovine serum albumin, exhibits strong endotoxic activity in a number of biological tests and leads to the production of specific antibodies to lipid A that are capable of cross-reacting with a large variety of lipopolysaccharides.
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Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice.
Ulrich E. Schaible,Michael D. Kramer,Klaus Eichmann,Manuel Modolell,Crisan Museteanu,Markus M. Simon +5 more
TL;DR: The identification of a B. burgdorferi-associated protective antigen suggests that the corresponding spirochetal protein should be tested as a vaccine against Lyme disease.
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Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response
Sunil S. Metkar,Cheikh Menaa,Julián Pardo,Julián Pardo,Baikun Wang,Reinhard Wallich,Marina A. Freudenberg,Stephen Kim,Srikumar M. Raja,Lianfa Shi,Markus M. Simon,Christopher J. Froelich +11 more
TL;DR: The granule secretory pathway plays an unexpected role in inflammation, with GzmA acting as an endogenous modulator.
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Complement Resistance of Borrelia burgdorferi Correlates with the Expression of BbCRASP-1, a Novel Linear Plasmid-encoded Surface Protein That Interacts with Human Factor H and FHL-1 and Is Unrelated to Erp Proteins
Peter Kraiczy,Jens Hellwage,Christine Skerka,Heiko Becker,Michael Kirschfink,Markus M. Simon,Volker Brade,Peter F. Zipfel,Reinhard Wallich +8 more
TL;DR: BbCRASP-1 binds the host complement regulators factor H and FHL-1 with high affinity, is the key molecule of the complement resistance of spirochetes, and is distinct from the Erp protein family.
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Gliotoxin Is a Virulence Factor of Aspergillus fumigatus: gliP Deletion Attenuates Virulence in Mice Immunosuppressed with Hydrocortisone
Janyce A. Sugui,Julián Pardo,Yun C. Chang,Kol A. Zarember,Glenn Nardone,Eva M. Galvez,Arno Müllbacher,John I. Gallin,Markus M. Simon,Kyung J. Kwon-Chung +9 more
TL;DR: It is confirmed that gliotoxin is an important virulence determinant of A. fumigatus and that the type of immunosuppression regimen used is important to reveal the pathogenic potential of gliot toxin.