S
Simona Iezzi
Researcher at National Institutes of Health
Publications - 30
Citations - 2425
Simona Iezzi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: DNA damage & Transcription (biology). The author has an hindex of 21, co-authored 29 publications receiving 2281 citations. Previous affiliations of Simona Iezzi include University of L'Aquila & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State
Marcella Fulco,R. Louis Schiltz,Simona Iezzi,M. Todd King,Po Zhao,Yoshihiro Kashiwaya,Eric P. Hoffman,Richard L. Veech,Vittorio Sartorelli +8 more
TL;DR: Results indicate that Sir2 regulates muscle gene expression and differentiation by possibly functioning as a redox sensor in response to exercise, food intake, and starvation, Sir2 may sense modifications of the redox state and promptly modulate gene expression.
Journal ArticleDOI
Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatin.
Simona Iezzi,Monica Di Padova,Carlo Serra,Giuseppina Caretti,Cristiano Simone,Eric Maklan,Giulia Minetti,Po Zhao,Eric P. Hoffman,Pier Lorenzo Puri,Vittorio Sartorelli +10 more
TL;DR: F follistatin is identified as a central mediator of the fusigenic effects exerted by deacetylase inhibitors on skeletal muscles and a rationale for their use to manipulate skeletal myogenesis and promote muscle regeneration is established.
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HERP, a Novel Heterodimer Partner of HES/E(spl) in Notch Signaling
Tatsuya Iso,Vittorio Sartorelli,Coralie Poizat,Simona Iezzi,Hung-Yi Wu,Gene Chung,Larry Kedes,Yasuo Hamamori +7 more
TL;DR: It is shown that HERP has intrinsic transcriptional repression activity, which means that Notch signaling relies on cooperation between HES and HERP, two transcriptional repressors with distinctive repression mechanisms which, either as homo- or as heterodimers, regulate target gene expression.
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Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis
Pier Lorenzo Puri,Pier Lorenzo Puri,Simona Iezzi,Peter Stiegler,Tung Ti Chen,R. Louis Schiltz,George E.O. Muscat,Antonio Giordano,Larry Kedes,Jean Y. J. Wang,Vittorio Sartorelli +10 more
TL;DR: It is suggested that reduced expression of HDAC1 accompanied by its redistribution in alternative nuclear protein complexes is critical for terminal differentiation of skeletal muscle cells.
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Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases
TL;DR: It is found that exposure of established rodent and human muscle cells to distinct DIs has stage-specific effects and the rationale for their use in manipulating adult and embryonic skeletal myogenesis is suggested.