M
Martha L. Ludwig
Researcher at University of Michigan
Publications - 85
Citations - 6215
Martha L. Ludwig is an academic researcher from University of Michigan. The author has contributed to research in topics: Methionine synthase & Flavodoxin. The author has an hindex of 42, co-authored 84 publications receiving 5951 citations.
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Journal ArticleDOI
The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia.
Brian D. Guenther,Christal A. Sheppard,Pamela V. Tran,Rima Rozen,Rowena G. Matthews,Martha L. Ludwig +5 more
TL;DR: Folate derivatives protect wild-type and mutant E. coli enzymes against flavin loss, and protect human MTHFR and the A222V mutant against thermal inactivation, suggesting a mechanism by which folate treatment reduces homocysteine levels.
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Thioredoxin reductase two modes of catalysis have evolved.
Charles H. Williams,Arscott Ld,Sylke Müller,Brett W. Lennon,Martha L. Ludwig,Pan-Fen Wang,Donna M. Veine,Katja Becker,R.H. Schirmer +8 more
TL;DR: It is hoped that the chemical difference between the two high Mr forms of thioredoxin reductase may be exploited for drug design.
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Structure-Based Perspectives on B12-Dependent Enzymes
TL;DR: Two X-ray structures of cobalamin (B12) bound to proteins have now been determined, revealing that the B12 cofactor undergoes a major conformational change on binding to the apoenzymes of methionine synthase and methylmalonyl-coenzyme A mutase: the dimethylbenzimidazole ligand to the cobalt is displaced by a histidine residue from the protein.
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Phthalate Dioxygenase Reductase: A Modular Structure for Electron Transfer from Pyridine Nucleotides to [2Fe-2S]
TL;DR: Structural and sequence similarities assign PDR to a distinct family of flavoprotein reductases, all related to ferredoxin NADP(+)-reductase, many of which are related to plant ferredoxins.
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Structure-function in Escherichia coli iron superoxide dismutase: comparisons with the manganese enzyme from Thermus thermophilus.
Myoung Soo Lah,Melinda M. Dixon,Katherine A. Pattridge,William C. Stallings,James A. Fee,Martha L. Ludwig +5 more
TL;DR: A reaction scheme in which the ligated solvent acts as a proton acceptor in the first half-reaction [formation of Fe(II) and oxygen] is consistent with the pH dependence of the kinetic parameters and spectroscopic properties of Fe superoxide dismutase.