M
Marthe J. Howard
Researcher at University of Toledo
Publications - 40
Citations - 1782
Marthe J. Howard is an academic researcher from University of Toledo. The author has contributed to research in topics: Neural crest & HAND2. The author has an hindex of 22, co-authored 38 publications receiving 1588 citations. Previous affiliations of Marthe J. Howard include Ohio University & University of Toledo Medical Center.
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Journal ArticleDOI
The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification
TL;DR: DHAND expression is sufficient to elicit the generation of ectopic sympathetic neurons in vivo and implicate a role for dHAND as transcriptional regulator downstream of Phox2b in BMP-induced sympathetic neuron differentiation.
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Mechanisms and perspectives on differentiation of autonomic neurons.
TL;DR: The studies reviewed here support the notion that neurotransmitter identity is closely linked to other aspects of neurogenesis and reveal a molecular mechanism to coordinate expression of pan-neuronal genes with cell type-specific genes.
Journal ArticleDOI
PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.
Beth A. Firulli,Marthe J. Howard,Jennifer R. Mcdaid,Leanne McIlreavey,Karen M Dionne,Victoria E. Centonze,Peter Cserjesi,David M. Virshup,Anthony B. Firulli +8 more
TL;DR: In this paper, the PP2A targeting-subunit B56δ specifically interacts with HAND1 and -2, but not other bHLH proteins, and the results suggest that site-specific phosphorylation regulates HAND factor functional specificity.
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Conditional Deletion of Hand2 Reveals Critical Functions in Neurogenesis and Cell Type-specific Gene Expression for Development of Neural Crest-derived Noradrenergic Sympathetic Ganglion Neurons
Tyler J. Hendershot,Hongbin Liu,David E. Clouthier,Iain T. Shepherd,Eva Coppola,Michèle Studer,Anthony B. Firulli,Douglas L. Pittman,Marthe J. Howard +8 more
TL;DR: The data suggest that Hand2 is a multifunctional DNA binding protein affecting differentiation and cell type-specific gene expression in neural crest-derived noradrenergic sympathetic ganglion neurons.
Journal ArticleDOI
Expression of HAND gene products may be sufficient for the differentiation of avian neural crest-derived cells into catecholaminergic neurons in culture.
TL;DR: The results suggest that the expression by neural crest cells of dHAND and eHAND may be both sufficient and necessary for catecholaminergic phenotypic expression.