M
Martin Anger
Researcher at University of Pennsylvania
Publications - 17
Citations - 2135
Martin Anger is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Separase & Chromosome segregation. The author has an hindex of 9, co-authored 14 publications receiving 2025 citations. Previous affiliations of Martin Anger include University of Oxford & Research Institute of Molecular Pathology.
Papers
More filters
Journal ArticleDOI
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes
Oliver H. Tam,Alexei A. Aravin,Paula Stein,Angélique Girard,Elizabeth P. Murchison,Sihem Cheloufi,Emily Hodges,Martin Anger,Martin Anger,Ravi Sachidanandam,Richard M. Schultz,Gregory J. Hannon +11 more
TL;DR: These findings indicate a function for pseudogenes in regulating gene expression by means of the RNA interference pathway and may, in part, explain the evolutionary pressure to conserve argonaute-mediated catalysis in mammals.
Journal ArticleDOI
Cell Cycle Synchronization of Porcine Fetal Fibroblasts: Effects of Serum Deprivation and Reversible Cell Cycle Inhibitors
Wilfried A. Kues,Martin Anger,Joseph Wallace Carnwath,David L. Paul,Jan Motlik,Heiner Niemann +5 more
TL;DR: Test data indicate that porcine fetal fibroblasts can be effectively synchronized at various cell cycle stages without compromising their proliferation capacity and suggest that somatic nuclear transfer critically depends on the cell cycle stage of the donor nucleus and the recipient cytoplast.
Journal ArticleDOI
Structure and function of the PP2A-shugoshin interaction
TL;DR: Evidence that PP2A's recruitment to chromosomes may be sufficient to protect cohesin from separase in mammalian oocytes is provided and crystal structure of a complex between a fragment of human Sgo1 and an AB'CPP2A holoenzyme reveals that Sgo 1 forms a homodimeric parallel coiled coil that docks simultaneously onto PP2 A's C and B' subunits.
Journal ArticleDOI
RNAi and expression of retrotransposons MuERV-L and IAP in preimplantation mouse embryos.
TL;DR: It is suggested that RNAi constrains expression of repetitive parasitic sequences in preimplantation embryos, and thereby contributes to preserving genomic integrity at a stage of development when the organism consists of only a few cells.
Journal ArticleDOI
Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint.
Barry E. McGuinness,Martin Anger,Anna Kouznetsova,Ana M. Gil-Bernabé,Wolfgang Helmhart,Nobuaki Kudo,Annelie Wuensche,Stephen S. Taylor,Christer Höög,Bela Novak,Kim Nasmyth +10 more
TL;DR: It is concluded that far from being absent or ineffective, the SAC largely determines the timing of APC/C and hence separase activation in oocytes, delaying it for about 5 hr.