N
Nahuel A. Paolini
Researcher at University of Amsterdam
Publications - 8
Citations - 181
Nahuel A. Paolini is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Translation (biology) & Messenger RNA. The author has an hindex of 5, co-authored 8 publications receiving 133 citations.
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Journal ArticleDOI
A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism
Nahuel A. Paolini,Martin Attwood,Samuel B. Sondalle,Carolina Marques dos Santos Vieira,Anita M. van Adrichem,Franca di Summa,Marie-Françoise O'Donohue,Pierre-Emmanuel Gleizes,Swaksha Rachuri,Joseph Briggs,Roman Fischer,Peter J. Ratcliffe,Marcin W. Wlodarski,Riekelt H. Houtkooper,Marieke von Lindern,Taco W. Kuijpers,Jonathan D. Dinman,Susan J. Baserga,Matthew E. Cockman,Alyson W. MacInnes +19 more
TL;DR: A ribosomopathy linked to uS12 is described and mechanistic distinctions between RP gene mutations driving hematopoietic disease and those resulting in developmental disorders are revealed.
Journal ArticleDOI
Distinct PKC-mediated posttranscriptional events set cytokine production kinetics in CD8+ T cells.
TL;DR: It is uncovered that each cytokine employs a private regulation of transcriptional and posttranscriptional events to guarantee appropriate production kinetics and PKC signaling modulates translation efficiency and mRNA stability in a transcript-specific manner.
Journal ArticleDOI
Recurring mutations in RPL15 are linked to hydrops fetalis and treatment independence in Diamond-Blackfan anemia
Marcin W. Wlodarski,Marcin W. Wlodarski,Lydie Da Costa,Marie-Françoise O'Donohue,Marc Gastou,Narjesse Karboul,Nathalie Montel-Lehry,Ina Hainmann,Dominika Danda,Amina Szvetnik,Victor B Pastor,Nahuel A. Paolini,Franca di Summa,Hannah Tamary,Hannah Tamary,Abed Abu Quider,Anna Aspesi,Riekelt H. Houtkooper,Thierry Leblanc,Charlotte M. Niemeyer,Charlotte M. Niemeyer,Pierre-Emmanuel Gleizes,Alyson W. MacInnes +22 more
TL;DR: This study identifies a novel subgroup of DBA with mutations in the RPL15 gene with an unexpected high rate of hydrops fetalis and spontaneous, long-lasting remission.
Journal ArticleDOI
Csde1 binds transcripts involved in protein homeostasis and controls their expression in an erythroid cell line.
Kat S. Moore,Nurcan Yagci,Floris P. J. van Alphen,Nahuel A. Paolini,Rastislav Horos,Ntsiki M. Held,Riekelt H. Houtkooper,Emile van den Akker,Alexander B. Meijer,Peter A C 't Hoen,Marieke von Lindern +10 more
TL;DR: It is suggested that Csde1 is involved in feed-back control in protein homeostasis and that it dampens stochastic changes in mRNA expression.
Journal ArticleDOI
Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors
Nahuel A. Paolini,Kat S. Moore,Franca di Summa,Ivo F.A.C. Fokkema,Peter A C 't Hoen,Peter A C 't Hoen,Marieke von Lindern +6 more
TL;DR: Investigation of how tunicamycin treatment, that induces eIF2 phosphorylation, affects mRNA translation in erythroblasts found novel translation initiation sites and uORFs following Harringtonine treatment uncovered.