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Christina Mecucci
Researcher at University of Perugia
Publications - 115
Citations - 5187
Christina Mecucci is an academic researcher from University of Perugia. The author has contributed to research in topics: Chromosomal translocation & Leukemia. The author has an hindex of 33, co-authored 115 publications receiving 4891 citations. Previous affiliations of Christina Mecucci include Katholieke Universiteit Leuven.
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Journal ArticleDOI
Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype
Brunangelo Falini,Christina Mecucci,Enrico Tiacci,Myriam Alcalay,Roberto Rosati,Laura Pasqualucci,Roberta La Starza,Daniela Diverio,Emanuela Colombo,Antonella Santucci,Barbara Bigerna,Roberta Pacini,Alessandra Pucciarini,Arcangelo Liso,Marco Vignetti,Paola Fazi,Natalia Meani,Valentina Pettirossi,Giuseppe Saglio,Franco Mandelli,Francesco Lo-Coco,Pier Giuseppe Pelicci,Massimo F. Martelli +22 more
TL;DR: Cytoplasmic NPM is a characteristic feature of a large subgroup of patients with AML who have a normal karyotype, NPM gene mutations, and responsiveness to induction chemotherapy.
Journal ArticleDOI
Marginal zone B-cell lymphomas of different sites share similar cytogenetic and morphologic features
Judith Dierlamm,Lucienne Michaux,Stefania Pittaluga,Iwona Wlodarska,Michel Stul,José Thomas,Marc Boogaerts,A. Driessen,Christina Mecucci,Jj. Cassiman,C. Dewolfpeeters,Hans Vandenberghe +11 more
TL;DR: It is concluded that MZBCL represent a distinct entity of B-NHL with characteristic morphologic and immunophenotypic features and particular chromosomal abnormalities, and that a close histogenetic relationship between extranodal, nodal, and splenic MzBCL is likely, although the clinical presentation may vary.
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Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia.
Nélida I. Noguera,Emanuele Ammatuna,Daniela Zangrilli,Serena Lavorgna,Mariadomenica Divona,Francesco Buccisano,Sergio Amadori,Christina Mecucci,Brunangelo Falini,Francesco Lo-Coco +9 more
TL;DR: A multiplex RT-PCR assay followed by capillary electrophoresis to simultaneously analyze NPM1 and Flt3 gene alterations (NFmPCR assays) is developed and suggested that this assay may be introduced in routine analysis of genetic alterations in AML.
Journal Article
A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL.
TL;DR: Two t(1;11)(p32;q11) translocations which fuse the HRX gene to a novel gene, AF-1p on chromosome 1p32, in two myeloid leukemias are characterized and indicate that AF- 1p defines another class of genes fused to HRX in 11q23 abnormalities.
Journal Article
Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia
A Martini,Roberta La Starza,Hilde Janssen,Chrystèle Bilhou-Nabera,Anniek Corveleyn,Riet Somers,Ana Aventin,Robin Foà,Anne Hagemeijer,Christina Mecucci,Peter Marynen +10 more
TL;DR: It is shown that, as result of a t(12;17)(p13;q11), the transcription factor gene CIZ/NMP4 is recurrently involved in acute leukemia through fusion with either EWSR1 or TAF15, suggesting a contribution to oncogenesis that is independent of the transactivating properties of the fusion protein.