M
Marcin W. Wlodarski
Researcher at St. Jude Children's Research Hospital
Publications - 158
Citations - 5087
Marcin W. Wlodarski is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Myelodysplastic syndromes & Biology. The author has an hindex of 33, co-authored 132 publications receiving 3972 citations. Previous affiliations of Marcin W. Wlodarski include University Medical Center Freiburg & Johns Hopkins University.
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Journal ArticleDOI
Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes
Felicitas Thol,Sofia Kade,Carola Schlarmann,Patrick Löffeld,Michael A. Morgan,Jürgen Krauter,Marcin W. Wlodarski,Britta Kölking,Martin Wichmann,Kerstin Görlich,Gudrun Göhring,Gesine Bug,Oliver G. Ottmann,Charlotte M. Niemeyer,Wolf-Karsten Hofmann,Brigitte Schlegelberger,Arnold Ganser,Michael Heuser +17 more
TL;DR: Results show a negative prognostic impact of SRSF2 mutations in MDS, which may become useful for clinical risk stratification and treatment decisions in the future.
Journal ArticleDOI
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia
Andres Jerez,Michael J. Clemente,Hideki Makishima,Hanna Koskela,Francis R LeBlanc,Kwok Peng Ng,Thomas L. Olson,Bartlomiej P Przychodzen,Manuel G. Afable,Inés Gómez-Seguí,Kathryn M Guinta,Lisa Durkin,Eric D. Hsi,Kathy L. McGraw,Dan Zhang,Marcin W. Wlodarski,Kimmo Porkka,Mikkael A. Sekeres,Alan F. List,Satu Mustjoki,Thomas P. Loughran,Jaroslaw P. Maciejewski +21 more
TL;DR: STAT3 mutations are frequent in large granular lymphocytes suggesting a similar molecular dysregulation in malignant chronic expansions of NK and CTL origin, and may distinguish truly malignant lymphoproliferations involving T and NK cells from reactive expansions.
Journal ArticleDOI
Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents.
Marcin W. Wlodarski,Marcin W. Wlodarski,Shinsuke Hirabayashi,Victor B Pastor,Jan Starý,Henrik Hasle,Riccardo Masetti,Michael Dworzak,Markus Schmugge,Marry M. van den Heuvel-Eibrink,Marek Ussowicz,Barbara De Moerloose,Albert Català,Owen P. Smith,Petr Sedlacek,Arjan C. Lankester,Marco Zecca,Victoria Bordon,Susanne Matthes-Martin,Jonas Abrahamsson,Jörn Sven Kühl,Karl Walter Sykora,Michael H. Albert,Bartlomiej Przychodzien,Jaroslaw P. Maciejewski,Stephan Schwarz,Gudrun Göhring,Brigitte Schlegelberger,Annamaria Cseh,Peter Noellke,Ayami Yoshimi,Franco Locatelli,Irith Baumann,Brigitte Strahm,Charlotte M. Niemeyer,Charlotte M. Niemeyer +35 more
TL;DR: GATA2 mutations are identified as the most common germline defect predisposing to pediatric MDS with a very high prevalence in adolescents with monosomy 7, and the high risk for progression to advanced disease must guide decision-making toward timely HSCT.
Journal ArticleDOI
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia
Mignon L. Loh,Debbie S Sakai,Christian Flotho,Michelle Kang,Manfred Fliegauf,Sophie Archambeault,Charles G. Mullighan,Leslie Chen,Eva Bergstraesser,Carlos E. Bueso-Ramos,Peter D. Emanuel,Henrik Hasle,Jean Pierre Issa,Marry M. van den Heuvel-Eibrink,Franco Locatelli,Jan Starý,Monica Trebo,Marcin W. Wlodarski,Marco Zecca,Kevin Shannon,Charlotte M. Niemeyer +20 more
TL;DR: The exclusivity of CBL mutations with respect to other Ras pathway-associated mutations indicates that CBL may have a role in deregulating this key pathway in JMML.
Journal ArticleDOI
CD4+CD25high Foxp3+ regulatory T cells in myelodysplastic syndrome (MDS)
Shahram Kordasti,Wendy Ingram,Janet Hayden,David Darling,Linda Barber,Behdad Afzali,Giovanna Lombardi,Marcin W. Wlodarski,Jaroslaw P. Maciejewski,Farzin Farzaneh,Ghulam J. Mufti +10 more
TL;DR: The data suggest that CD4+ Treg expansion is a feature of high-risk MDS and progression to aggressive subtypes of the disease.