Martin Bonke

TL;DR: Unique molecular identifiers (UMIs), which make each molecule in a population distinct, are applied to genome-scale human karyotyping and mRNA sequencing in Drosophila melanogaster to improve accuracy of almost any next-generation sequencing method.

TL;DR: In the Arabidopsis root meristem, xylem cell lineages are specified early, whereas phloem and procambium are established through a set of asymmetric cell divisions that require the WOODEN LEG (WOL) gene.

TL;DR: The results indicate that even relatively small differences in in vitro binding specificity of a TF contribute to site selectivity in vivo, and this work identifies amino‐acid residues that are critical for the differences in specificity between all the classes.

TL;DR: The studies suggest that APL has a dual role both in promoting phloem differentiation and in repressing xylem differentiation during vascular development, and that Ectopic APL expression in the vascular bundle inhibitsxylem development.

TL;DR: A high-throughput method for analyzing transcription factor binding specificity that is based on systematic evolution of ligands by exponential enrichment (SELEX) and massively parallel sequencing is described and reveals unexpected dimeric modes of binding for several factors that were thought to preferentially bind DNA as monomers.