Andrew R. Gehrke

TL;DR: A broad survey of transcription factors reveals that related proteins can have multiple and differing DNA binding specificities, which may be important in gene regulation and in the evolution of transcriptional regulatory networks.

TL;DR: A computational system is developed that successfully predicts binding sites for homeodomain proteins as distant from mouse as Drosophila and C. elegans, and the results provide an unprecedented level of resolution in the analysis of this simple domain structure and suggest that variation in sequence recognition may be a factor in its functional diversity and evolutionary success.

TL;DR: The results indicate that even relatively small differences in in vitro binding specificity of a TF contribute to site selectivity in vivo, and this work identifies amino‐acid residues that are critical for the differences in specificity between all the classes.

TL;DR: In this article, the authors sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD).

TL;DR: Novel connections between the archetypal loops of the Arabidopsis clock represent a significant advance toward defining the molecular dynamics underlying the circadian network in plants and provide the first mechanistic insight into the molecular function of the previously orphan clock factor LUX.