M
Martin Granzow
Researcher at Heidelberg University
Publications - 54
Citations - 5466
Martin Granzow is an academic researcher from Heidelberg University. The author has contributed to research in topics: Exome sequencing & Comparative genomic hybridization. The author has an hindex of 25, co-authored 53 publications receiving 4947 citations. Previous affiliations of Martin Granzow include German Cancer Research Center & University Hospital Heidelberg.
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Journal ArticleDOI
The RIN: an RNA integrity number for assigning integrity values to RNA measurements
Andreas Schroeder,Odilo Mueller,Susanne Dr. Stocker,Susanne Dr. Stocker,Ruediger Salowsky,Michael Leiber,Marcus Gassmann,Samar Lightfoot,Wolfram Menzel,Martin Granzow,Thomas Ragg +10 more
TL;DR: The results show the importance of taking characteristics of several regions of the recorded electropherogram into account in order to get a robust and reliable prediction of RNA integrity, especially if compared to traditional methods.
Journal ArticleDOI
From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression.
Oleg Schmidt-Kittler,Thomas Ragg,Angela Daskalakis,Martin Granzow,A. Ahr,Thomas Blankenstein,Manfred Kaufmann,Joachim Diebold,Hans Arnholdt,P. Müller,Joachim Bischoff,Detlev Harich,Günter Schlimok,Gert Riethmüller,Roland Eils,Christoph Klein +15 more
TL;DR: It is suggested that in breast cancer, tumor cells may disseminate in a far less progressed genomic state than previously thought, and that they acquire genomic aberrations typical of metastatic cells thereafter.
BookDOI
A Practical Approach to Microarray Data Analysis
TL;DR: A Practical Approach to Microarray Data Analysis is intended for students, teachers, researchers, and research managers who want to understand the state of the art and of the presented methodologies and the areas in which gaps in knowledge demand further research and development.
Journal ArticleDOI
Progression in Smoldering Myeloma Is Independently Determined by the Chromosomal Abnormalities del(17p), t(4;14), Gain 1q, Hyperdiploidy, and Tumor Load
Kai Neben,Anna Jauch,Thomas Hielscher,Jens Hillengass,Nicola Lehners,Anja Seckinger,Martin Granzow,Marc-Steffen Raab,Anthony D. Ho,Hartmut Goldschmidt,Dirk Hose +10 more
TL;DR: The high-risk chromosomal aberrations del(17p13), t(4;14), and +1q21 are adverse prognostic factors in SMM just as they are in active myeloma, independent of tumor mass.
Journal ArticleDOI
Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2
Stefan Joos,Martin Granzow,Heidi Holtgreve-Grez,Reiner Siebert,Lana Harder,José I. Martín-Subero,Jürgen Wolf,Martyna Adamowicz,Thomas F. E. Barth,Peter Lichter,Anna Jauch +10 more
TL;DR: Previous cytogenetic results from primary Hodgkin's tumors suggest an important pathogenic role of REL and JAK2 in this disease, and provide evidence for a novel cytogenetics pathomechanism leading to increased copy numbers of putative oncogenes from terminal chromosomal regions, most probably in the course of chromosomal stabilization by telomeric capture.