Martin von Bergen

TL;DR: It is hypothesized that pyroptotic cell death by the Nucleotide‐Binding Domain, Leucine‐Rich-Containing Family, Pyrin Domain‐Containing‐3 (Nlrp3) inflammasome plays an essential role during human and murine cholestasis.

TL;DR: This study shows that the regulation of MV activity is one important mode of action of GAGs and provides information on underlying molecular mechanisms.

TL;DR: Highly conserved amino acid residues that were proposed to be specifically involved in the decarboxylation of the intermediate glutaconyl-CoA were identified inGDH(Geo) but are missing in GDH(Des), and the differential use of energy-yielding/energy-demanding enzymatic processes in anaerobic bacteria that degrade aromatic compounds is discussed.

TL;DR: LSG leads to changes in amino acids and in lipid metabolism indicated by glycerol-phosphatidylcholines and SM, and the pattern of protein biomarkers and metabolites might provide measures for the induced physiological changes and for therapy monitoring.

TL;DR: The anatomical rearrangement in RYGB affects microbiota composition and functionality as well as changes in amino acid and bile acid metabolism independently of weight loss, and the shift in the taxonomic structure of the microbiota after RyGB may be mediated by the resulting change in the composition of the bile Acid pool in the gut and by changes in the compositions of nutrients in the Gut.