TOPICAL REVIEW: Applications of magnetic nanoparticles in biomedicine

The physical principles underlying some current biomedical applications of magnetic nanoparticles are reviewed. Starting from well-known basic concepts, and drawing on examples from biology and biomedicine, the relevant physics of magnetic materials and their responses to applied magnetic fields are surveyed. The way these properties are controlled and used is illustrated with reference to (i) magnetic separation of labelled cells and other biological entities; (ii) therapeutic drug, gene and radionuclide delivery; (iii) radio frequency methods for the catabolism of tumours via hyperthermia; and (iv) contrast enhancement agents for magnetic resonance imaging applications. Future prospects are also discussed.

https://iopscience.iop.org/article/10.1088/0022-3727/36/13/201/pdf

Applications of magnetic nanoparticles in biomedicine

Biocompatibility, Pharmaceutical and Biomedical Applications L. Harivardhan Reddy,†,‡ Jose ́ L. Arias, Julien Nicolas,† and Patrick Couvreur*,† †Laboratoire de Physico-Chimie, Pharmacotechnie et Biopharmacie, Universite ́ Paris-Sud XI, UMR CNRS 8612, Faculte ́ de Pharmacie, IFR 141, 5 rue Jean-Baptiste Cleḿent, F-92296 Chat̂enay-Malabry, France Departamento de Farmacia y Tecnología Farmaceútica, Facultad de Farmacia, Campus Universitario de Cartuja s/n, Universidad de Granada, 18071 Granada, Spain ‡Pharmaceutical Sciences Department, Sanofi, 13 Quai Jules Guesdes, F-94403 Vitry-sur-Seine, France

Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications.

http://pharmaquest.weebly.com/uploads/9/9/4/2/9942916/superparamagnetic_iron_oxide_nanoparticles_spions.pdf

Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy

Proteins, through their unique and specific interactions with other macromolecules and inorganics, control structures and functions of all biological hard and soft tissues in organisms. Molecular biomimetics is an emerging field in which hybrid technologies are developed by using the tools of molecular biology and nanotechnology. Taking lessons from biology, polypeptides can now be genetically engineered to specifically bind to selected inorganic compounds for applications in nano- and biotechnology. This review discusses combinatorial biological protocols, that is, bacterial cell surface and phage-display technologies, in the selection of short sequences that have affinity to (noble) metals, semiconducting oxides and other technological compounds. These genetically engineered proteins for inorganics (GEPIs) can be used in the assembly of functional nanostructures. Based on the three fundamental principles of molecular recognition, self-assembly and DNA manipulation, we highlight successful uses of GEPI in nanotechnology.

/pdf/molecular-biomimetics-nanotechnology-through-biology-3l16jci9jq.pdf

Molecular biomimetics: nanotechnology through biology

This paper describes the preparation, characterization and compare of three different modes for coupling biologically active substances to magnetic particles: (i) covalently bound proteins and enzymes to freshly prepared magnetite in the presence of carbodiimide (CDI), (ii) the encapsulation of magnetic nanoparticles and drugs in lipid mixture dipalmitoylphosphatidylcholine (DPPC) and (iii) the encapsulation of magnetic nanoparticles and drugs in biodegradable poly D,L-lactide polymer (PLA).

Some immobilization modes of biologically active substances to fine magnetic particles

in 6CHBT-Based Ferronematics N. Toma2ovi£ova, M. Timko, M. Koneracka, V. Zavi2ova, J. Jad»yn, E. Beaugnon, X. Chaud and P. Kop£anský Institute of Experimental Physics, Slovak Academy of Science, Watsonova 47, 040 01 Ko2ice, Slovakia Institute of Molecular Physics, Polish Academy of Sciences, M. Smoluchowskiego 17, 60-179 Pozna«, Poland High Magnetic Field Laboratory, CNRS, 25 Avenue des Martyrs, Grenoble, France

/pdf/magnetic-field-induced-structural-transitions-in-6chbt-based-2tary031jo.pdf

Magnetic Field Induced Structural Transitions in 6CHBT-Based Ferronematics

The structural transitions in ferronematics based on the thermotropic nematic liquid crystal 4-cyano-4’-hexylbiphenyl were studied. The ferronematic samples were prepared by doping with magnetic suspension consisting of Fe3O4 particles (10 nm in diameter) coated with oleic acid as a surfactant with different volume concentrations of magnetic particles (from 10−5 to 10−3). Freedericksz transitions were studied in combined electric and magnetic fields. The experimental results indicated soft anchoring with perpendicular initial orientation between the magnetic moment of the magnetic particles and director.

/pdf/the-structural-phase-transitions-in-6cb-based-ferronematics-2a61wcd8wf.pdf

The Structural Phase Transitions in 6CB-Based Ferronematics

The presented chapter provides an overview of selected magnetic nanoparticle systems (magnetic fluids, magnetosomes, magnetoferritin and liquid crystals doped with magnetic particles) as the unique materials with potential utilization in the field of biological and biomedical applications as well as in the field of technology. The main idea for magnetic nanoparticles incorporating is the improvement of material properties and to achieve better conditions for a wide range of scientific disciplines such as magnetic hyperthermia, drug delivery, magneto-optics, power engineering and others.

Magnetic Fluids and Their Complex Systems

Presence of protein amyloid deposits is associated with pathogenesis of amyloid-related diseases. Insulin amyloid aggregates have been reported in a patient with diabetes undergoing treatment by injection of insulin. We have investigated the interference of insulin amyloid aggregation with two Fe3O4-based magnetic fluids. The magnetic fluids are able to inhibit insulin amyloid fibrillization and promote disassembly of amyloid fibrils. The cytotoxic effect of amyloid fibrils is attenuated in presence of magnetic fluids probably due to reduction of the fibrils. We suggest that present findings propose the potential use of Fe3O4-based magnetic fluids as the therapeutic agents targeting insulin-associating amyloidosis.

/pdf/attenuation-of-the-insulin-amyloid-aggregation-in-presence-5gr193d3w5.pdf

Martina Koneracka

Papers

Some immobilization modes of biologically active substances to fine magnetic particles

Magnetic Field Induced Structural Transitions in 6CHBT-Based Ferronematics

The Structural Phase Transitions in 6CB-Based Ferronematics

Magnetic Fluids and Their Complex Systems

Attenuation of the insulin amyloid aggregation in presence of Fe3O4-based magnetic fluids.