M
Martina Lerche
Researcher at Åbo Akademi University
Publications - 12
Citations - 641
Martina Lerche is an academic researcher from Åbo Akademi University. The author has contributed to research in topics: Integrin & Mechanotransduction. The author has an hindex of 10, co-authored 11 publications receiving 385 citations. Previous affiliations of Martina Lerche include University of Turku.
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Journal ArticleDOI
Democratising deep learning for microscopy with ZeroCostDL4Mic.
Lucas von Chamier,Romain F. Laine,Romain F. Laine,Johanna Jukkala,Christoph Spahn,Daniel Krentzel,Daniel Krentzel,Elias Nehme,Martina Lerche,Sara Hernández-Pérez,Sara Hernández-Pérez,Pieta K. Mattila,Pieta K. Mattila,Eleni Karinou,Seamus Holden,Ahmet Can Solak,Alexander Krull,Tim-Oliver Buchholz,Martin L. Jones,Loic Royer,Christophe Leterrier,Yoav Shechtman,Florian Jug,Mike Heilemann,Guillaume Jacquemet,Ricardo Henriques,Ricardo Henriques,Ricardo Henriques +27 more
TL;DR: ZeroCostDL4Mic as discussed by the authors is an entry-level platform simplifying DL access by leveraging the free, cloud-based computational resources of Google Colab, which allows researchers with no coding expertise to train and apply key DL networks to perform tasks including segmentation, object detection, denoising, and image-to-image translation.
Journal ArticleDOI
AMPK negatively regulates tensin-dependent integrin activity
Maria Georgiadou,Johanna Lilja,Guillaume Jacquemet,Camilo Guzmán,Maria Rafaeva,Charlotte Alibert,Yan Yan,Pranshu Sahgal,Martina Lerche,Jean-Baptiste Manneville,Tomi P. Mäkelä,Johanna Ivaska +11 more
TL;DR: It is shown that the loss of AMPK up-regulates tensins, which bind &bgr;1-integrins, supporting their activity and promoting fibrillar adhesion formation and integrin-dependent processes.
Journal ArticleDOI
Targeting β1-integrin inhibits vascular leakage in endotoxemia.
Laura Hakanpaa,Elina A. Kiss,Guillaume Jacquemet,Ilkka Miinalainen,Martina Lerche,Camilo Guzmán,Eero Mervaala,Lauri Eklund,Johanna Ivaska,Johanna Ivaska,Pipsa Saharinen +10 more
TL;DR: It is shown that antibodies against β1-integrin decrease LPS-induced vascular leakage in murine endotoxemia, as either a preventative or an intervention therapy.
Journal ArticleDOI
A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion.
Elisa Närvä,Aki Stubb,Camilo Guzmán,Matias Blomqvist,Diego Balboa,Martina Lerche,Markku Saari,Timo Otonkoski,Johanna Ivaska,Johanna Ivaska +9 more
TL;DR: In this article, the actin fence encircling the colony was found to exert extensive Rho-ROCK-myosin-dependent mechanical stress to enforce colony morphology, compaction, and pluripotency and to define mitotic spindle orientation.
Posted ContentDOI
ZeroCostDL4Mic: an open platform to simplify access and use of Deep-Learning in Microscopy
Lucas von Chamier,Johanna Jukkala,Christoph Spahn,Martina Lerche,Sara Hernández-Pérez,Pieta K. Mattila,Eleni Karinou,Seamus Holden,Ahmet Can Solak,Alexander Krull,Tim-Oliver Buchholz,Florian Jug,Loic Royer,Mike Heilemann,Romain F. Laine,Guillaume Jacquemet,Ricardo Henriques +16 more
TL;DR: A platform simplifying access to DL by exploiting the free, cloud-based computational resources of Google Colab is presented, which allows researchers to train, evaluate, and apply key DL networks to perform tasks including segmentation, detection, denoising, restoration, resolution enhancement and image-to-image translation.