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Markku Saari
Researcher at University of Turku
Publications - 13
Citations - 665
Markku Saari is an academic researcher from University of Turku. The author has contributed to research in topics: Focal adhesion & Integrin. The author has an hindex of 8, co-authored 13 publications receiving 511 citations. Previous affiliations of Markku Saari include VTT Technical Research Centre of Finland & Åbo Akademi University.
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Journal ArticleDOI
Integrin endosomal signalling suppresses anoikis.
Jonna Alanko,Jonna Alanko,Anja Mai,Guillaume Jacquemet,Kristine Schauer,Riina Kaukonen,Markku Saari,Markku Saari,Bruno Goud,Johanna Ivaska,Johanna Ivaska +10 more
TL;DR: It is shown that active focal adhesion kinase (FAK), an established marker of integrin–ECM downstream signalling, localizes with active integrins on endosomes and becomes activated on them, suggesting a role for endocytosis in enhancing distinct integrin downstream signalling events.
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Vimentin–ERK Signaling Uncouples Slug Gene Regulatory Function
Reetta Virtakoivu,Reetta Virtakoivu,Anja Mai,Elina Mattila,Elina Mattila,Nicola De Franceschi,Nicola De Franceschi,Susumu Y. Imanishi,Garry L. Corthals,Riina Kaukonen,Riina Kaukonen,Markku Saari,Markku Saari,Fang Cheng,Fang Cheng,Elin Torvaldson,Elin Torvaldson,Veli-Matti Kosma,Arto Mannermaa,Ghaffar Muharram,Ghaffar Muharram,Christine Gilles,John E. Eriksson,Ylermi Soini,James B. Lorens,Johanna Ivaska,Johanna Ivaska +26 more
TL;DR: A novel vimentin-ERK axis that regulates the transcriptional activity of Slug (SNAI2) is described, which identified a pivotal step in controlling the ability of Slug to organize hallmarks of EMT.
Journal ArticleDOI
Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription.
Riina Kaukonen,Anja Mai,Maria Georgiadou,Markku Saari,Nicola De Franceschi,Timo Betz,Harri Sihto,Sami Ventelä,Sami Ventelä,Laura L. Elo,Eija Jokitalo,Jukka Westermarck,Pirkko-Liisa Kellokumpu-Lehtinen,Heikki Joensuu,Heikki Joensuu,Reidar Grénman,Johanna Ivaska +16 more
TL;DR: It is shown that extracellular matrix generated by normal fibroblasts (NFs) is softer than the CAF matrix, and its physical and structural features regulate cancer cell proliferation, resulting in the epigenetic growth restriction of carcinoma cells through JMJD1a-dependent modulation of gene expression.
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Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells.
Aki Stubb,Camilo Guzmán,Elisa Närvä,Jesse Aaron,Teng-Leong Chew,Markku Saari,Mitro Miihkinen,Guillaume Jacquemet,Johanna Ivaska,Johanna Ivaska +9 more
TL;DR: Using superresolution two-colour interferometric photo-activated localisation microscopy, the authors describe features in the nanoscale makeup of these stable FAs such as inverted vinculin, lateral talin segregation and distinct kank protein distributions.
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A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion.
Elisa Närvä,Aki Stubb,Camilo Guzmán,Matias Blomqvist,Diego Balboa,Martina Lerche,Markku Saari,Timo Otonkoski,Johanna Ivaska,Johanna Ivaska +9 more
TL;DR: In this article, the actin fence encircling the colony was found to exert extensive Rho-ROCK-myosin-dependent mechanical stress to enforce colony morphology, compaction, and pluripotency and to define mitotic spindle orientation.