Mary Farrington

TL;DR: It is reported that patients with hyper-IgM syndrome (HIM) have a defective gp39-CD40 interaction, which suggests that a defect in gp39 is the basis of X-linked HIM.

TL;DR: In this paper, CD40 ligand (gp39) mRNA expression by activated lymphocytes from CVI patients as a group was significantly depressed (P < 0.0001) compared with normal controls (n = 32).

TL;DR: In this paper, B cells from all CVI patients underwent normal proliferation and synthesized normal quantities of IgE in the presence of anti-CD40 and IL-4, and four patterns of Ig isotype synthesis were observed.

TL;DR: Patients and guinea pigs deficient of early complement component and LAD patients responded to repeated phage immunization with depressed antibody titers, lack of or inadequate amplification, and failure to switch from IgM to IgG, suggesting a defect in generating antigen-specific memory cells.

TL;DR: It is demonstrated that IL-2 plays an active role in the regulation of Ig production via CD40 by anti-CD40-activated B cells, suggesting that in a subgroup of CVI patients theIL-2 deficiency may contribute to the observed hypogammaglobulinemia.