M
Masahiro Uehira
Researcher at Kumamoto University
Publications - 16
Citations - 1549
Masahiro Uehira is an academic researcher from Kumamoto University. The author has contributed to research in topics: Genetically modified mouse & NOD mice. The author has an hindex of 13, co-authored 16 publications receiving 1527 citations.
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Journal ArticleDOI
Experimental metastasis is suppressed in MMP-9-deficient mice.
Takeshi Itoh,Masatoshi Tanioka,Hidetoshi Matsuda,Hirofumi Nishimoto,Takayuki Yoshioka,Ryuji Suzuki,Masahiro Uehira +6 more
TL;DR: Results indicated that host-derived MMP-9 plays an important role in the process of tumor metastasis, and Gelatin zymography showed that both tumor cell lines did not secrete M MP-9 by themselves but the host cells surrounding the tumor cells secretion in vivo.
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Interleukin 7 Transgenic Mice Develop Chronic Colitis with Decreased Interleukin 7 Protein Accumulation in the Colonic Mucosa
Mamoru Watanabe,Yoshitaka Ueno,Tomoharu Yajima,Susumu Okamoto,Tatsuhiko Hayashi,Motomi Yamazaki,Yasushi Iwao,Hiromasa Ishii,Sonoko Habu,Masahiro Uehira,Hirofumi Nishimoto,Hiromichi Ishikawa,Jun-ichi Hata,Toshifumi Hibi +13 more
TL;DR: The findings suggest that chronic inflammation in the colonic mucosa may be mediated by dysregulation of colonic epithelial cell–derived IL-7, and this murine model of chronic colitis may contribute to the understanding of the pathogenesis of human inflammatory bowel disease.
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Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene.
Yoshihiro Ogawa,Hiroshi Itoh,Naohisa Tamura,Shin Ichi Suga,Takaaki Yoshimasa,Masahiro Uehira,Saburo Matsuda,Shozo Shiono,Hirofumi Nishimoto,Kazuwa Nakao +9 more
TL;DR: It is demonstrated that these mice provide a useful model system with which to assess the roles of BNP in cardiovascular regulation and the potential usefulness of B NP as a long-term therapeutic agent is suggested.
Journal ArticleDOI
Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice
Toru Miyazaki,Masashi Uno,Masahiro Uehira,Hitoshi Kikutani,Tadamitsu Kishimoto,Masao Kimoto,Hirofumi Nishimoto,Junichi Miyazaki,Ken Ichi Yamamura +8 more
TL;DR: The results show that the single amino-acid substitution at position 57 of the I-A β-chain from aspartic acid to serine is not sufficient for the development of the disease.
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Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide
Michio Suda,Yoshihiro Ogawa,Kiyoshi Tanaka,Naohisa Tamura,Akihiro Yasoda,Toshiya Takigawa,Masahiro Uehira,Hirofumi Nishimoto,Hiroshi Itoh,Yoshihiko Saito,Kohei Shiota,Kazuwa Nakao +11 more
TL;DR: It is demonstrated that natriuretic peptides can affect the process of endochondral ossification, and marked skeletal overgrowth in transgenic mice that overexpress BNP is reported.