J
Junichiro Irie
Researcher at Keio University
Publications - 91
Citations - 2473
Junichiro Irie is an academic researcher from Keio University. The author has contributed to research in topics: Diabetes mellitus & Type 2 diabetes. The author has an hindex of 22, co-authored 80 publications receiving 1677 citations. Previous affiliations of Junichiro Irie include Japan Agency for Medical Research and Development & University of Pittsburgh.
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Journal ArticleDOI
Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice
Ikuo Kimura,Ikuo Kimura,Junki Miyamoto,Junki Miyamoto,Ryuji Ohue-Kitano,Ryuji Ohue-Kitano,Keita Watanabe,Takahiro G. Yamada,Masayoshi Onuki,Ryo Aoki,Ryo Aoki,Yosuke Isobe,Daiji Kashihara,Daisuke Inoue,Akihiko Inaba,Yuta Takamura,Satsuki Taira,Shunsuke Kumaki,Masaki Watanabe,Masato Ito,Fumiyuki Nakagawa,Junichiro Irie,Junichiro Irie,Hiroki Kakuta,Masakazu Shinohara,Ken Iwatsuki,Gozoh Tsujimoto,Hiroaki Ohno,Hiroaki Ohno,Makoto Arita,Makoto Arita,Hiroshi Itoh,Hiroshi Itoh,Koji Hase,Koji Hase +34 more
TL;DR: The authors found that maternal microbiota during pregnancy imparts resistance to obesity to their offspring, and raise the possibility that maternal SCFAs play a key role in the regulation of disease susceptibility during postnatal life in the context of the DOHaD theory.
Journal ArticleDOI
Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids.
Junki Miyamoto,Junki Miyamoto,Miki Igarashi,Keita Watanabe,Shin-ichiro Karaki,Hiromi Mukouyama,Shigenobu Kishino,Xuan Li,Atsuhiko Ichimura,Junichiro Irie,Junichiro Irie,Yukihiko Sugimoto,Yukihiko Sugimoto,Tetsuya Mizutani,Tatsuya Sugawara,Takashi Miki,Jun Ogawa,Daniel J. Drucker,Makoto Arita,Hiroshi Itoh,Hiroshi Itoh,Ikuo Kimura,Ikuo Kimura +22 more
TL;DR: It is demonstrated that intestinal bacteria metabolize dietary linoleic acid to 10-hydroxy-cis-12-octadecenoic acid (HYA) which confers host resistance to high fat diet-induced obesity in mice, thereby shedding light on the prevention and treatment of metabolic disorders by targeting gut microbial metabolites.
Journal ArticleDOI
NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis
Junichiro Irie,Yuehong Wu,Linda S. Wicker,Daniel B. Rainbow,Michael A. Nalesnik,Raphael Hirsch,Laurence B. Peterson,Patrick S.C. Leung,Chunmei Cheng,Ian R. Mackay,M. Eric Gershwin,William M. Ridgway +11 more
TL;DR: It is demonstrated that NOD.c3c4 mice congenically derived from the nonobese diabetic strain develop an autoimmune biliary disease (ABD) that models human PBC, and the first ABD (Abd) locus is defined using a congenic mapping approach.
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Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians
Yuko Sato,Koji Atarashi,Damian R. Plichta,Yasumichi Arai,Satoshi Sasajima,Sean M. Kearney,Wataru Suda,Kozue Takeshita,Takahiro Sasaki,Shoki Okamoto,Ashwin N. Skelly,Yuki Okamura,Hera Vlamakis,Youxian Li,Takeshi Tanoue,Hajime Takei,Hiroshi Nittono,Seiko Narushima,Junichiro Irie,Hiroshi Itoh,Kyoji Moriya,Yuki Sugiura,Makoto Suematsu,Nobuko Moritoki,Shinsuke Shibata,Dan R. Littman,Dan R. Littman,Michael A. Fischbach,Yoshifumi Uwamino,Takashi Inoue,Akira Honda,Masahira Hattori,Tsuyoshi Murai,Ramnik J. Xavier,Ramnik J. Xavier,Nobuyoshi Hirose,Kenya Honda +36 more
TL;DR: In this paper, the authors show that centenarians have a distinct gut microbiome that is enriched in microorganisms that are capable of generating unique secondary bile acids, including various isoforms of lithocholic acid (LCA): iso-, 3-oxo-, allo-, 3oxoallo- and isoallolithocholic acids.
Journal ArticleDOI
Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes
Keiichi Kodama,Momoko Horikoshi,Kyoko Toda,Satoru Yamada,Hara Kazuo,Junichiro Irie,Marina Sirota,Marina Sirota,Alexander A. Morgan,Alexander A. Morgan,Rong Chen,Rong Chen,Hiroshi Ohtsu,Shiro Maeda,Takashi Kadowaki,Atul J. Butte,Atul J. Butte +16 more
TL;DR: This work performed an eGWAS across 130 independent experiments to find additional genes implicated in the molecular pathogenesis of T2D and identified the immune-cell receptor CD44 as the top candidate, likely plays a causative role in the development of adipose tissue inflammation and insulin resistance in rodents and humans.