Showing papers in "Mechanisms of Ageing and Development in 1992"

TL;DR: The most interesting finding was a contrasting age-change in two subsets of CD4+ T cells; i.e. a subset of suppressor inducer T cells (CD4+CD45RA+ naive cells) decreased with age, while a subset that showed an increase in numbers with age.

TL;DR: Using the anti-lipoperoxidative measure of dietary restriction on membranes, evidence is presented to support the possibility that age-related peroxidation of membrane lipids may play a significant role in bringing about fluidity changes in aged membranes.

TL;DR: There might be a functional relationship between the observed age-changes in the ciliary muscle system and the phenomenon of the so-called 'lens paradox' (steepening of the anterior and posterior curvatures of the disaccommodated lens with age).

TL;DR: Results suggest that the significance of the changes of these antioxidant enzyme activities during aging needs to be carefully interpreted, taking into consideration the fact that changes are markedly variable depending on sex as well as the organs and brain regions examined.

TL;DR: The increase in the activities of the anti-oxidant enzymes of the red blood cells during aging, could be interpreted as a positive feedback mechanism in response to rising lipid peroxidation.

TL;DR: The finding that wheel running prevented atrophy with ageing of the weight-bearing soleus but not of the non-weight-bearing EDL emphasizes the specificity of exercise, and shows that exercise-induced muscle hypertrophy can be maintained in old age by appropriate exercise.

TL;DR: Performance of a new non-invasive test of the human hepatic glucocorticoid-inducible CYP3A in a geriatric cohort suggests that the gender-related heterogeneity in function of the glucoc Corticoid inducible human CYP2A persists during normal aging, and that the activity of CYP 3A may decrease in obesity.

TL;DR: The overall antioxidant capacity of rat tissues appears to be maintained without large variation during ageing, and decreases in the capacity of some antioxidant factors may be compensated by increases in thecapacity of other factors.

TL;DR: The results suggest that the aging process in brain is accompanied by alterations in both dynamic aspects ofCa2+ handling in nerve endings and the overall content of Ca2+ in the brain and synaptic terminals.

TL;DR: The positive effect on the increased shift of these cells from one morphotype to the other by two different stresses firms one of the prediction of the thermodynamic model which states that cellular aging can be considered as a multi-step process which can be speeded up by various external modifications.

TL;DR: Results of this study indicate that 14% of the normal level of catalase activity allows flies to achieve both a normal life span and a normal metabolic potential.

TL;DR: Modification of the fatty acyl composition of phospholipid fractions of spleen cell membranes may facilitate binding of IL-2 and insulin to their receptors and thus may improve T cell proliferation and prevent or delay age-related loss in immune functions.

TL;DR: These studies show that density-arrested, serum-deprived, quiescent young and senescent cells express a number of genes differentially, which are not growth-dependent, but are age-dependent.

TL;DR: In order to examine the wider applicability of a Gompertzian model to ALS the technique has been replicated with the mortality rates for England and Wales for the 27-year period from 1963 to 1989 and extended to produce an estimate of the size of the inherently susceptible sub-population (both male and female) over the entire period.

TL;DR: These studies suggest that an age-related decrease in plasma membrane viscosity is associated with a decrease in O2- production and adherence of neutrophils to components of the extracellular matrix and may result in diminished neutrophil function and increased susceptibility to infection with pyogenic bacteria.

TL;DR: Results extend the findings demonstrating that older subjects display an impairment of T cell functions and that IL-2 treatment may correct these alterations and confirm the hypothesis that age-associated functional changes are more likely due to diminished numbers of reactive cells, than to a decline in the activity of all cells.

TL;DR: The data allow us to suggest that the activity of brain dopaminergic neurons is modified with aging and there are significant differences as a function of sex and brain area.

TL;DR: The results suggest that the competitive and deterministic features of the Gompertzian model of human aging and mortality remain valid through age 96 years and cover the vast majority of human mortality.

TL;DR: It is concluded that aging in rats is associated with alterations in cerebral microvascular reactivity in vivo along with arteriovenous shunting which may contribute to age-related alterations in the blood-brain barrier (BBB) function.

TL;DR: The results of this initial study of embryonic chick antioxidant systems suggest that certain antioxidants may be regulated by PO2 and rate of oxidative metabolism during fetal development.

TL;DR: It is concluded that chronic administration of nimodipine delays the formation of microvascular deposits up to the age of 30 months, and in a very late stage of the ageing process collagen fibrils in microv vascular fibrotic plaques are depolymerized and degradated.

TL;DR: The results suggest that the rise of serum levels of individual immunoglobulin isotypes associated with ageing is usually the consequence of a polyclonal B cell activation.

TL;DR: The protein synthetic rate in the yeast S. cerevisiae, measured by the incorporation of radioactive amino acids per unit amount of proteins, decreased linearly with age reaching 50% of the rate of 2nd generation cells (young cells) in 20thgeneration cells (old cells), whereas the RNA content of the old cells was increased three times.

TL;DR: The results of this study indicate that the muscular forces applied by the swim training protocol produced greater bone adaptations than the forces applications by a running protocol of equal duration and intensity.

TL;DR: Oxygen acts as a lifespan determinant of the nematode and when the animals were exposed to a high concentration of oxygen at the early phase of lifespan, the oxygen-induced lifespanShortening was not observed, which means that oxygen- induced damage leading to lifespan shortening is repaired under 21% oxygen and that the oxygen -induced lifespanshortening does not result from any alteration in development and/or mutation.

TL;DR: Investigation of mortality trends and patterns in industrialized countries suggests that age-specific mortality rates are an interrelated deterministic function of aggregate genetic, environmental and competitive influences.

TL;DR: The oxidation-enhanced carbonyl-protein cross-linking is suggested to be an important chemical reaction which may take place during ageing and be involved in lipofuscinogenesis.

TL;DR: Addition of suramin and monensin suppressed the migration of fibroblasts from fetal, adult and elderly donors, which implies that fibroblast migration is regulated by growth factors and matrix substances.

TL;DR: Findings indicate that, relative to factors that affect the recruitment and differentiation of osteoclast precursor cells, bone matrix of older individuals is changed in quality and/or quantity compared to bone matrix from younger individuals.

TL;DR: The fluidity of the erythrocyte membrane derived from growing rats raised under restricted food intake was found to be higher than the fluidities of the respective membranes from ad libitum fed animals, suggesting the possible beneficial effects of food restriction at a young age.