M
Masao Yamaguchi
Researcher at Kyoto University
Publications - 5
Citations - 903
Masao Yamaguchi is an academic researcher from Kyoto University. The author has contributed to research in topics: HBG2 & MYB. The author has an hindex of 4, co-authored 5 publications receiving 834 citations. Previous affiliations of Masao Yamaguchi include University of Oxford & French Alternative Energies and Atomic Energy Commission.
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Journal ArticleDOI
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.
Stephan Menzel,Chad Garner,Ivo Gut,Fumihiko Matsuda,Masao Yamaguchi,Simon Heath,Mario Foglio,Diana Zelenika,Anne Boland,Helen Rooks,Steve Best,Tim D. Spector,Martin Farrall,G. Mark Lathrop,Swee Lay Thein,Swee Lay Thein +15 more
TL;DR: A genome-wide association mapping strategy is applied to individuals with contrasting extreme trait values and a new F cell quantitative trait locus is mapped to BCL11A, which encodes a zinc-finger protein, on chromosome 2p15.
Journal ArticleDOI
Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults.
Swee Lay Thein,Stephan Menzel,Xu Peng,Steve Best,Jie Jiang,James Close,James Close,Nicholas Silver,Ageliki Gerovasilli,Chen Ping,Masao Yamaguchi,Karin Wahlberg,Pinar Ulug,Tim D. Spector,Chad Garner,Fumihiko Matsuda,Martin Farrall,Mark Lathrop +17 more
TL;DR: The results support a key role for the HBS1L-related genetic variants in HbF control and illustrate the biological complexity of the mechanism of 6q QTL as a modifier of fetal hemoglobin levels in the β hemoglobinopathies.
Journal ArticleDOI
The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells
Karin Wahlberg,Jie Jiang,Helen Rooks,Kiran Jawaid,Fumihiko Matsuda,Fumihiko Matsuda,Masao Yamaguchi,Masao Yamaguchi,Mark Lathrop,Swee Lay Thein,Swee Lay Thein,Steve Best +11 more
TL;DR: This study provides the functional link between genetic association of HMIP with control of fetal hemoglobin and other hematologic parameters and presents a large-scale analysis of histone acetylation as well as RNA polymerase II and GATA-1 interactions on chromosome 6q, and alpha and beta globin gene loci.
Journal ArticleDOI
A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations.
Roubila Meziani,Ryo Yamada,Meiko Takahashi,Kenei Ohigashi,Akio Morinobu,Chikashi Terao,Hitomi Hiratani,Koichiro Ohmura,Masao Yamaguchi,Takashi Nomura,Alexandre Vasilescu,Miki Kokubo,Victor Renault,Katsura Hirosawa,Chanavee Ratanajaraya,Simon Heath,Tsuneyo Mimori,Shimon Sakaguchi,Mark Lathrop,Inga Melchers,Shunichi Kumagai,Fumihiko Matsuda +21 more
TL;DR: The DerSimonian–Laird test for meta-analysis, using the combined results of the two populations, identified rs7551957 at the 5′-flanking region of the low-affinity Fc-gamma receptor IIa (FCGR2A) gene as the strongest candidate for the association.
Journal ArticleDOI
Intergenic variants of HBSIL-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing HbF levels in adults.
Swee Lay Thein,Stephan Menzel,Xu Peng,Steve Best,Jie Jiang,James Close,James Close,Nicholas Silver,Ageliki Gerovasilli,Chen Ping,Masao Yamaguchi,Karin Wahlberg,Heike Muller,Tim D. Spector,Chad Garner,Fumihiko Matsuda,Martin Farrall,Mark Lathrop +17 more
TL;DR: This research highlights the need to understand more fully the rationale for the continued use of antipsychotic medication in patients with severe psychiatric illness.