Matt Morenzoni

TL;DR: A genome sequencing platform that achieves efficient imaging and low reagent consumption with combinatorial probe anchor ligation chemistry to independently assay each base from patterned nanoarrays of self-assembling DNA nanoballs is described.

TL;DR: A dense map of genetic variation in the laboratory mouse genome will provide insights into the evolutionary history of the species and lead to an improved understanding of the relationship between inter-strain genotypic and phenotypic differences.

TL;DR: Novel computational methods developed for accurate calling of SNPs and short substitutions and indels (<100 bp) are described and the same methods apply to evaluation of hypothesized larger, structural variations.

TL;DR: In this article, the authors provide methods and systems for precisely and consistently fragmenting and labeling nucleic acid fragments. Time and temperature programmable temperature control modules are used to provide repeatable time/temperature profiles for fragmentation and labeling reactions.