M
Matt S. Hepburn
Researcher at Harry Perkins Institute of Medical Research
Publications - 18
Citations - 212
Matt S. Hepburn is an academic researcher from Harry Perkins Institute of Medical Research. The author has contributed to research in topics: Elastography & Optical coherence tomography. The author has an hindex of 5, co-authored 10 publications receiving 87 citations. Previous affiliations of Matt S. Hepburn include University of Western Australia.
Papers
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Journal ArticleDOI
Strain and elasticity imaging in compression optical coherence elastography: The two‐decade perspective and recent advances
Vladimir Y. Zaitsev,Alexander L. Matveyev,Lev A. Matveev,Alexander A. Sovetsky,Matt S. Hepburn,Matt S. Hepburn,Alireza Mowla,Alireza Mowla,Brendan F. Kennedy,Brendan F. Kennedy +9 more
TL;DR: The underlying principles of C-OCE are focused on, various practical challenges in its realization are discussed and examples of biomedical applications of the technique are presented.
Journal ArticleDOI
Volume Adaptation Controls Stem Cell Mechanotransduction
Luke G. Major,Andrew W. Holle,Jennifer L. Young,Jennifer L. Young,Matt S. Hepburn,Kwanghee Jeong,Ian L. Chin,Rowan W. Sanderson,Rowan W. Sanderson,Ji Hoon Jeong,Zachary M. Aman,Brendan F. Kennedy,Brendan F. Kennedy,Brendan F. Kennedy,Yongsung Hwang,Dong-Wook Han,Hyun Woo Park,Kun-Liang Guan,Joachim P. Spatz,Joachim P. Spatz,Yu Suk Choi +20 more
TL;DR: Volume adaptation as a function of 3D matrix stiffness can control stem cell mechanotransduction and differentiation.
Journal ArticleDOI
Analysis of spatial resolution in phase-sensitive compression optical coherence elastography
TL;DR: It is demonstrated for the first time, through close correspondence between experiment and simulation of structured phantoms, that resolution in compression OCE is both spatially varying and sample dependent, which is linked to the discrepancies between the model of elasticity and the mechanical deformation of the sample.
Journal ArticleDOI
Three-dimensional imaging of cell and extracellular matrix elasticity using quantitative micro-elastography
Matt S. Hepburn,Philip Wijesinghe,Luke G. Major,Jiayue Li,Alireza Mowla,Chrissie J. Astell,Hyun Woo Park,Yongsung Hwang,Yu Suk Choi,Brendan F. Kennedy +9 more
TL;DR: It is shown that QME can reveal elevated elasticity surrounding human adipose-derived stem cells (ASCs) embedded in soft hydrogels and further elevation of extracellular elasticity around ASCs with overexpressed TAZ; a mechanosensitive transcription factor which regulates cell volume.
Journal ArticleDOI
Enhancing Resistance of Silk Fibroin Material to Enzymatic Degradation by Cross-Linking Both Crystalline and Amorphous Domains.
Filippo Valente,Benjamin J. Allardyce,Matt S. Hepburn,Matt S. Hepburn,Philip Wijesinghe,Philip Wijesinghe,Philip Wijesinghe,Sharon L. Redmond,Jingyu Chen,Brendan F. Kennedy,Brendan F. Kennedy,Rangam Rajkhowa,Marcus D. Atlas,Xungai Wang,Rodney J. Dilley +14 more
TL;DR: It is hypothesized that photo-cross-linking protects the SF amorphous regions from enzymatic degradation and complements the natural protection offered by β-sheets in the crystalline region, and presents broad utility in tissue engineering applications that require a long-term degradation profile and mechanical support.