M
Matthew G. Oser
Researcher at Harvard University
Publications - 30
Citations - 3600
Matthew G. Oser is an academic researcher from Harvard University. The author has contributed to research in topics: Invadopodia & Cortactin. The author has an hindex of 18, co-authored 27 publications receiving 2983 citations. Previous affiliations of Matthew G. Oser include Albert Einstein College of Medicine & Yeshiva University.
Papers
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Journal ArticleDOI
Targeting oncoproteins with a positive selection assay for protein degraders.
Vidyasagar Koduri,Leslie Duplaquet,Benjamin L. Lampson,Adam C. Wang,Amin H. Sabet,Mette Ishoey,Joshiawa Paulk,Mingxing Teng,Isaac S. Harris,Isaac S. Harris,Jennifer E. Endress,Jennifer E. Endress,Xiaoxi Liu,Ethan Dasilva,Joao A. Paulo,Kimberly J. Briggs,John G. Doench,Christopher J. Ott,Tinghu Zhang,Katherine A. Donovan,Eric S. Fischer,Steven P. Gygi,Nathanael S. Gray,James E. Bradner,Jeffrey A. Medin,Sara J. Buhrlage,Matthew G. Oser,Matthew G. Oser,William G. Kaelin,William G. Kaelin,William G. Kaelin +30 more
TL;DR: In this article, the authors describe a gain of signal ("up") assay for degraders in arrayed chemical screens, which can facilitate the identification of drugs that directly or indirectly degrade undruggable proteins.
Journal ArticleDOI
A Severe Photosensitivity Dermatitis Caused by Crizotinib
Journal ArticleDOI
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
Samuel K. McBrayer,Benjamin A. Olenchock,Gabriel J. DiNatale,Diana D. Shi,Januka Khanal,Rebecca B. Jennings,Rebecca B. Jennings,Jesse Novak,Jesse Novak,Matthew G. Oser,Alissa Robbins,Rebecca Modiste,Dennis M. Bonal,Javid Moslehi,Roderick T. Bronson,Donna Neuberg,Quang-Dé Nguyen,Sabina Signoretti,Sabina Signoretti,Julie-Aurore Losman,William G. Kaelin +20 more
TL;DR: It is shown that conditional, systemic ablation of RBP2 in tumor-bearing Rb1+/− mice is sufficient to slow tumor growth and significantly extend survival without causing obvious toxicity to the host.
Book ChapterDOI
Actin-based Motile Processes in Tumor Cell Invasion
TL;DR: This chapter discusses the molecular mechanisms that are known to control the actin cytoskeleton during the formation and maturation of both lamellipodia and invadopodia, and the contribution of these actin-based motile processes to the invasive tumor cell phenotype during metastasis in vivo.
Journal ArticleDOI
Small-Cell Neuroendocrine Tumors: Cell State Trumps the Oncogenic Driver
TL;DR: Phenotypically, small-cell carcinoma of the bladder (SCCB) shares many similarities with small- cell lung cancer (SCLC), but it is unknown whether SCCB and SCLC share common genetic driver mutations.