M
Matthew G. Oser
Researcher at Harvard University
Publications - 30
Citations - 3600
Matthew G. Oser is an academic researcher from Harvard University. The author has contributed to research in topics: Invadopodia & Cortactin. The author has an hindex of 18, co-authored 27 publications receiving 2983 citations. Previous affiliations of Matthew G. Oser include Albert Einstein College of Medicine & Yeshiva University.
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Journal ArticleDOI
CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
Hua Zhang,Camilla L. Christensen,Ruben Dries,Matthew G. Oser,Jiehui Deng,Brian Diskin,Fei Li,Yuanwang Pan,Xuzhu Zhang,Yandong Yin,Eleni Papadopoulos,Val Pyon,Cassandra Thakurdin,Nicholas Kwiatkowski,Kandarp Jani,Alexandra R. Rabin,Dayanne M. Castro,Ting Chen,Heather Silver,Qingyuan Huang,Mirna Bulatović,Catríona M. Dowling,Belen Sundberg,Alan L. Leggett,Michela Ranieri,Han Han,Shuai Li,Annan Yang,Kristen E. Labbe,Christina Almonte,Vladislav O. Sviderskiy,Max M. Quinn,Jack Donaghue,Eric S. Wang,Tinghu Zhang,Zhixiang He,Vamsidhar Velcheti,Peter S. Hammerman,Gordon J. Freeman,Richard Bonneau,William G. Kaelin,William G. Kaelin,Kate D. Sutherland,Kate D. Sutherland,Ariena Kersbergen,Andrew J. Aguirre,Andrew J. Aguirre,Guo-Cheng Yuan,Eli Rothenberg,George Miller,Nathanael S. Gray,Kwok-Kin Wong +51 more
TL;DR: It is demonstrated that CDK7 inhibition predominately disrupts cell-cycle progression and induces DNA replication stress and genome instability in small cell lung cancer (SCLC) while simultaneously triggering immune-response signaling.
Journal ArticleDOI
N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells.
Vera DesMarais,Hideki Yamaguchi,Matthew G. Oser,Lilian Soon,Ghassan Mouneimne,Corina Sarmiento,Robert J. Eddy,John S. Condeelis +7 more
TL;DR: In this paper, invadopodia formation on glass requires N-WASP and cortactin but not microtubules, and depletion of either protein inhibits chemotaxis of cells towards EGF.
Journal ArticleDOI
Cells Lacking the RB1 Tumor Suppressor Gene are Hyperdependent on Aurora B Kinase for Survival
Matthew G. Oser,Matthew G. Oser,Raquel Fonseca,Abhishek A. Chakraborty,Rachel Brough,Alexander Spektor,Alexander Spektor,Alexander Spektor,Rebecca B. Jennings,Abdallah Flaifel,Jesse Novak,Aditi Gulati,Elizabeth J. Buss,Elizabeth J. Buss,Scott T. Younger,Samuel K. McBrayer,Glenn S. Cowley,Dennis M. Bonal,Quang-Dé Nguyen,Laura Brulle-Soumare,Paula Taylor,Stefano Cairo,Colm J. Ryan,Elizabeth Janet Pease,Kim Maratea,Jon Travers,David E. Root,Sabina Signoretti,David Pellman,David Pellman,Susan Ashton,Christopher J. Lord,Simon T. Barry,William G. Kaelin +33 more
TL;DR: A CRISPR/Cas9-based screen showed that RB1 -/- SCLC are hyperdependent on AURKB, likely because both genes control mitotic fidelity, and confirmed that Aurora B kinase inhibitors are efficacious against RB1-/- SclC tumors in mice at nontoxic doses.
Journal ArticleDOI
Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.
Isaac S. Harris,Isaac S. Harris,Jennifer E. Endress,Jennifer E. Endress,Jonathan L. Coloff,Jonathan L. Coloff,Laura M. Selfors,Samuel K. McBrayer,Jennifer M. Rosenbluth,Jennifer M. Rosenbluth,Nobuaki Takahashi,Nobuaki Takahashi,Sabin Dhakal,Vidyasagar Koduri,Matthew G. Oser,Nathan J. Schauer,Laura M. Doherty,Andrew L. Hong,Andrew L. Hong,Andrew L. Hong,Yun Pyo Kang,Scott T. Younger,John G. Doench,William C. Hahn,William C. Hahn,William C. Hahn,Sara J. Buhrlage,Gina M. DeNicola,William G. Kaelin,Joan S. Brugge,Joan S. Brugge +30 more
TL;DR: It is indicated that depletion of GSH renders cancer cells dependent on DUB activity to maintain protein homeostasis and cell viability and reveal a potentially exploitable vulnerability for cancer therapy.
Journal ArticleDOI
New Approaches to SCLC Therapy: From the Laboratory to the Clinic
John T. Poirier,Julie George,Taofeek K. Owonikoko,Anton Berns,Elisabeth Brambilla,Lauren Averett Byers,David P. Carbone,Huanhuan Joyce Chen,Camilla L. Christensen,Caroline Dive,Anna F. Farago,Ramaswamy Govindan,Christine L. Hann,Matthew D. Hellmann,Leora Horn,Jane E. Johnson,Young Seok Ju,Sumin Kang,Mark A. Krasnow,James L. Lee,Se-Hoon Lee,Jonathan M. Lehman,Benjamin H. Lok,Christine M. Lovly,David MacPherson,David G. McFadden,John D. Minna,Matthew G. Oser,Keunchil Park,Kwon-Sik Park,Yves Pommier,Vito Quaranta,Neal Ready,Julien Sage,Giorgio V. Scagliotti,Martin L. Sos,Kate D. Sutherland,William D. Travis,Christopher R. Vakoc,Sarah J. Wait,Ignacio I. Wistuba,Kwok-Kin Wong,Hua Zhang,Jillian B. Daigneault,Jacinta Wiens,Charles M. Rudin,Trudy G. Oliver +46 more
TL;DR: This review largely summarizes work presented at the Third Biennial IASLC Small Cell Lung Cancer Meeting and identifies key knowledge gaps that should be addressed in order to advance the field in pursuit of reduced small cell lung cancer mortality.