M
Matthew H. Burke
Researcher at Ohio State University
Publications - 4
Citations - 76
Matthew H. Burke is an academic researcher from Ohio State University. The author has contributed to research in topics: Myeloid leukemia & Notch signaling pathway. The author has an hindex of 3, co-authored 4 publications receiving 41 citations.
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Journal ArticleDOI
Prognostic and biological significance of the proangiogenic factor EGFL7 in acute myeloid leukemia.
Dimitrios Papaioannou,Changxian Shen,Deedra Nicolet,Deedra Nicolet,Betina McNeil,Marius Bill,Malith Karunasiri,Matthew H. Burke,Hatice Gulcin Ozer,Selen A. Yilmaz,Nina C. Zitzer,Gregory K. Behbehani,Christopher C. Oakes,Damian J Steiner,Guido Marcucci,Bayard L. Powell,Jonathan E. Kolitz,Thomas H. Carter,Eunice S. Wang,Krzysztof Mrózek,Carlo M. Croce,Michael A. Caligiuri,Clara D. Bloomfield,Ramiro Garzon,Adrienne M. Dorrance +24 more
TL;DR: The results show that AML blasts are able to synthesize and secrete EGFL7 protein, promoting autocrine blast cell growth and providing the rationale for targeting EG FL7 using blocking antibodies as a therapy for patients with AML.
Journal ArticleDOI
Spinal cord injury causes chronic bone marrow failure
Randall S. Carpenter,Jessica M. Marbourg,Faith H. Brennan,Katherine A. Mifflin,Jodie C. E. Hall,Roselyn R. Jiang,Xiaokui M. Mo,Malith Karunasiri,Matthew H. Burke,Adrienne M. Dorrance,Phillip G. Popovich +10 more
TL;DR: It is shown that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration, thereby entrapping them in the bone marrow and disrupting peripheral immune homeostasis.
Journal ArticleDOI
EGFL7 Antagonizes NOTCH Signaling and Represents a Novel Therapeutic Target in Acute Myeloid Leukemia.
Marius Bill,Aparna Pathmanathan,Malith Karunasiri,Changxian Shen,Matthew H. Burke,Parvathi Ranganathan,Dimitrios Papaioannou,Nina C. Zitzer,Katiri Snyder,Allison LaRocco,Allison E. Walker,Zachary Brannan,Ansel P. Nalin,Aharon G. Freud,Mikhail M. Dikov,Xiaoli Zhang,Clara D. Bloomfield,Ramiro Garzon,Adrienne M. Dorrance +18 more
TL;DR: Reactivation of NOTCH signaling in vivo using anti-EGFL7 results in prolonged survival of leukemic mice, supporting the use of EGFL7 as a novel therapeutic target in AML.
Journal ArticleDOI
EGFL7 Antagonizes NOTCH Signaling, Stimulates Blast Proliferation and Confers Poor Prognosis in Cytogenetically-Normal Acute Myeloid Leukemia (CN-AML)
Changxian Shen,Dimitrios Papaioannou,Betina McNeil,Deedra Nicolet,Malith Karunasiri,Matthew H. Burke,Zitzer Nina,Gregory K. Behbehani,Hatice Gulcin Ozer,Selen A. Yilmaz,Guido Marcucci,Michael A. Caligiuri,Clara D. Bloomfield,Ramiro Garzon,Adrienne M. Dorrance +14 more
TL;DR: EGFL7 is associated with worse prognosis in patients with CN-AML, and that EG FL7 is expressed and secreted by the AML cells in an autocrine fashion, promoting their growth in part through antagonizing NOTCH2 activation.