M
Malith Karunasiri
Researcher at Ohio State University
Publications - 10
Citations - 370
Malith Karunasiri is an academic researcher from Ohio State University. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 7, co-authored 10 publications receiving 246 citations.
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Journal ArticleDOI
MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling
Jae Sung Yi,Jun Sub Park,Young Mi Ham,Nga Nguyen,Na Rae Lee,Jin Hong,Bong Woo Kim,Hyun Geun Lee,Chang Seok Lee,Byung Cheon Jeong,Hyun Kyu Song,Hana Cho,Yoon Ki Kim,Jae Seon Lee,Kyong Soo Park,Haksub Shin,Inho Choi,Seung Hee Lee,Woo Jin Park,Shi Young Park,Cheol Soo Choi,Pei-Hui Lin,Malith Karunasiri,Tao Tan,Pu Duann,Hua Zhu,Jianjie Ma,Young Gyu Ko +27 more
TL;DR: It is shown that MG53 is an ubiquitin E3 ligase that induces IRS-1 ubiquitination with the help of an E2-conjugating enzyme, UBE2H, which abolishes E3-ligase function of MG53 and enhances skeletal myogenesis.
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The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.
Dimitrios Papaioannou,Andreas Petri,Oliver M. Dovey,Sara Terreri,Eric Wang,Frances A. Collins,Lauren A. Woodward,Allison E. Walker,Deedra Nicolet,Deedra Nicolet,Felice Pepe,Prasanthi Kumchala,Marius Bill,Christopher J. Walker,Malith Karunasiri,Krzysztof Mrózek,Miranda L. Gardner,Virginia Camilotto,Virginia Camilotto,Nina C. Zitzer,Jonathan L. Cooper,Xiongwei Cai,Xiaoqing Rong-Mullins,Jessica Kohlschmidt,Jessica Kohlschmidt,Kellie J. Archer,Michael A. Freitas,Yi Zheng,Robert J. Lee,Iannis Aifantis,George S. Vassiliou,George S. Vassiliou,Guramrit Singh,Sakari Kauppinen,Clara D. Bloomfield,Adrienne M. Dorrance,Ramiro Garzon +36 more
TL;DR: It is proposed that in the context of NPM1 mutations, HOXB-AS3 overexpression acts as a compensatory mechanism, which allows adequate protein production in leukemic blasts.
Journal ArticleDOI
Expression and functional relevance of long non-coding RNAs in acute myeloid leukemia stem cells
Marius Bill,Dimitrios Papaioannou,Malith Karunasiri,Jessica Kohlschmidt,Felice Pepe,Christopher J. Walker,Allison E. Walker,Zachary Brannan,Aparna Pathmanathan,Xiaoli Zhang,Krzysztof Mrózek,Allison LaRocco,Stefano Volinia,Clara D. Bloomfield,Ramiro Garzon,Adrienne M. Dorrance +15 more
TL;DR: It is shown that targeting Dancr in vivo using a primary murine model of AML prolonged the survival of mice after serial transplantation and suggested that LSCs have a distinct lncRNA signature with functional relevance and therapeutic potential.
Journal ArticleDOI
Knockout of both miR-15/16 loci induces acute myeloid leukemia.
Francesca Lovat,Matteo Fassan,Diana Sacchi,Parvathi Ranganathan,Alexey Palamarchuk,Marius Bill,Malith Karunasiri,Pierluigi Gasparini,Giovanni Nigita,Rosario Distefano,Dario Veneziano,Adrienne M. Dorrance,Ramiro Garzon,Carlo M. Croce +13 more
TL;DR: A driver oncogenic role for miR-15/16 cluster deletion in different leukocytic cell lineages is identified and suggested that a fraction of AML could be caused the by the loss of miR/16 clusters.
Journal ArticleDOI
Prognostic and biological significance of the proangiogenic factor EGFL7 in acute myeloid leukemia.
Dimitrios Papaioannou,Changxian Shen,Deedra Nicolet,Deedra Nicolet,Betina McNeil,Marius Bill,Malith Karunasiri,Matthew H. Burke,Hatice Gulcin Ozer,Selen A. Yilmaz,Nina C. Zitzer,Gregory K. Behbehani,Christopher C. Oakes,Damian J Steiner,Guido Marcucci,Bayard L. Powell,Jonathan E. Kolitz,Thomas H. Carter,Eunice S. Wang,Krzysztof Mrózek,Carlo M. Croce,Michael A. Caligiuri,Clara D. Bloomfield,Ramiro Garzon,Adrienne M. Dorrance +24 more
TL;DR: The results show that AML blasts are able to synthesize and secrete EGFL7 protein, promoting autocrine blast cell growth and providing the rationale for targeting EG FL7 using blocking antibodies as a therapy for patients with AML.