M
Matthew J. Dalby
Researcher at University of Glasgow
Publications - 278
Citations - 18719
Matthew J. Dalby is an academic researcher from University of Glasgow. The author has contributed to research in topics: Nanotopography & Mesenchymal stem cell. The author has an hindex of 65, co-authored 260 publications receiving 16664 citations. Previous affiliations of Matthew J. Dalby include Autonomous University of Barcelona & Norwich Research Park.
Papers
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Journal ArticleDOI
The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
Matthew J. Dalby,Nikolaj Gadegaard,Rahul S. Tare,Abhay Andar,Mathis O. Riehle,Pawel Herzyk,Chris D. W. Wilkinson,Richard O.C. Oreffo +7 more
TL;DR: The use of nanoscale disorder is demonstrated to stimulate human mesenchymal stem cells (MSCs) to produce bone mineral in vitro, in the absence of osteogenic supplements, which has implications for cell therapies.
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Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate
TL;DR: How cell adhesions interact with nanotopography is discussed, and insight is provided as to how materials scientists can exploit these interactions to direct stem cell fate and to understand how the behaviour of stem cells in their niche can be controlled.
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Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency
Rebecca J. McMurray,Nikolaj Gadegaard,P. Monica Tsimbouri,Karl Burgess,Laura E. McNamara,Rahul S. Tare,Kate Murawski,Emmajayne Kingham,Richard O.C. Oreffo,Richard O.C. Oreffo,Matthew J. Dalby +10 more
TL;DR: The study identifies a nanostructured surface that retains stem-cell phenotype and maintains stem- cell growth over eight weeks, and implicates a role for small RNAs in repressing key cell signalling and metabolomic pathways, demonstrating the potential of surfaces as non-invasive tools with which to address the stem cell niche.
Journal ArticleDOI
In vitro reaction of endothelial cells to polymer demixed nanotopography.
Matthew J. Dalby,Mathis O. Riehle,Heather J H Johnstone,Stanley Affrossman,Adam S. G. Curtis +4 more
TL;DR: In this paper, the authors used polymer demixing of polystyrene and poly(4-bromostyrene) producing nanometrically high islands, and observed endothelial cell response to the islands.
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Nanotopographical modification: a regulator of cellular function through focal adhesions
TL;DR: This review focuses on the recent developments concerning the role of nanoscale structures on integrin-mediated adhesion and cellular function with an emphasis on the generation of medical constructs with regenerative applications.