M
Matthew Riopel
Researcher at University of California, San Diego
Publications - 25
Citations - 1967
Matthew Riopel is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Islet. The author has an hindex of 15, co-authored 24 publications receiving 1322 citations. Previous affiliations of Matthew Riopel include University of Western Ontario.
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Journal ArticleDOI
Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity.
Wei Ying,Matthew Riopel,Gautam Bandyopadhyay,Yi Dong,Amanda Birmingham,Jong Bae Seo,Jachelle M. Ofrecio,Joshua Wollam,Angelina Hernandez-Carretero,Wenxian Fu,Pingping Li,Jerrold M. Olefsky +11 more
TL;DR: These studies show that ATMs in obese mice secrete exosomes containing miRNA cargo, which can be transferred to insulin target cell types through mechanisms of paracrine or endocrine regulation with robust effects on cellular insulin action, in vivo insulin sensitivity, and overall glucose homeostasis.
Journal ArticleDOI
Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity
Wei Ying,Matthew Riopel,Gautam Bandyopadhyay,Dong Y,Amanda Birmingham,Bae Seo J,Jachelle M. Ofrecio,Joshua Wollam,Angelina Hernandez-Carretero,Wenxian Fu,Pingping Li,Jerrold M. Olefsky +11 more
Journal ArticleDOI
Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity
Wei Ying,Yun Sok Lee,Yi Dong,Jason S. Seidman,Meixiang Yang,Roi Isaac,Jong Bae Seo,Bi-Huei Yang,Joshua Wollam,Matthew Riopel,Joanne C. McNelis,Christopher K. Glass,Jerrold M. Olefsky,Wenxian Fu +13 more
TL;DR: This work identifies two islet-resident macrophage populations, characterized by their anatomical distributions, distinct phenotypes, and functional properties, and defines distinct roles and mechanisms for islet macrophages in the regulation of islet β cells.
Journal ArticleDOI
Conditional β1‐integrin‐deficient mice display impaired pancreatic β cell function
TL;DR: It is demonstrated that β1‐integrin is involved in the regulation of glucose metabolism and contributes to the maintenance of β cell survival and function in vivo.
Journal ArticleDOI
Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.
Jong Bae Seo,Matthew Riopel,Pedro Cabrales,Jin Young Huh,Gautam Bandyopadhyay,Aleksander Andreyev,Anne N. Murphy,Scott C. Beeman,Gordon I. Smith,Samuel Klein,Samuel Klein,Yun Sok Lee,Jerrold M. Olefsky +12 more
TL;DR: The authors show that adipocyte oxygen consumption increases early after onset of high-fat diet feeding owing to activation of the mitochondrial protein AnT2 and that specific inhibition of ANT2 reduces adipose tissue hypoxia, inflammation and insulin resistance.