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Matthew S. Miller

Researcher at McMaster University

Publications -  102
Citations -  3941

Matthew S. Miller is an academic researcher from McMaster University. The author has contributed to research in topics: Medicine & Virus. The author has an hindex of 25, co-authored 77 publications receiving 2569 citations. Previous affiliations of Matthew S. Miller include McMaster-Carr & Icahn School of Medicine at Mount Sinai.

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Differential Biodistribution of Adenoviral-Vectored Vaccine Following Intranasal and Endotracheal Deliveries Leads to Different Immune Outcomes

TL;DR: Compared to intranasal delivery, the deepened and widened biodistribution in the lung following endotracheal delivery is associated with much improved vaccine-mediated immunogenicity and protection against the target pathogen.
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Sputnik-V reactogenicity and immunogenicity in the blood and mucosa: a prospective cohort study

TL;DR: In this paper , the authors performed a prospective cohort study to assess the reactogenicity and immunologic outcomes of Sputnik-V vaccination in Kazakhstan, and found that most of the reported adverse events were mild-to-moderate injection site or systemic reactions, no severe or potentially life-threatening conditions were reported, and dose 1 appeared to be more reactogenic than dose 2.
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Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections

TL;DR: In this paper, the authors investigated lasting changes to soluble inflammatory factors and cellular immune phenotype and function in individuals who had recovered from mild SARS-CoV-2 infections (n = 22) compared to those that had been previously infected with other mild respiratory infections, and found that significantly more T-cells could be activated by polyclonal stimulation compared to individuals with other recent respiratory infections.
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High SARS-CoV-2 seroprevalence in Karaganda, Kazakhstan before the launch of COVID-19 vaccination

TL;DR: Overall, SARS-CoV-2 exposure in this cohort was ~15-fold higher compared to the reported all-time national and regional COVID-19 prevalence, consistent with recent studies of excess infection and death in Kazakhstan.