M
Mangalakumari Jeyanathan
Researcher at McMaster University
Publications - 53
Citations - 3103
Mangalakumari Jeyanathan is an academic researcher from McMaster University. The author has contributed to research in topics: Immunity & Tuberculosis vaccines. The author has an hindex of 23, co-authored 43 publications receiving 2208 citations. Previous affiliations of Mangalakumari Jeyanathan include University College London.
Papers
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Journal ArticleDOI
Immunological considerations for COVID-19 vaccine strategies.
Mangalakumari Jeyanathan,Sam Afkhami,Fiona Smaill,Matthew S. Miller,Brian D. Lichty,Zhou Xing +5 more
TL;DR: The immunological principles that need to be taken into consideration in the development of COVID-19 vaccine strategies are discussed and their strengths and potential shortfalls are examined, and inferences about their chances of success are made.
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Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection.
Rogelio Hernández-Pando,Mangalakumari Jeyanathan,Getahun Mengistu,Diana Aguilar,Héctor Fabio Bermúdez Orozco,Morten Harboe,Graham A. W. Rook,Gunnar Bjune +7 more
TL;DR: Findings contradict the dominant view that latent organisms exist in old classic tuberculous lesions, and have important implications for strategies aimed at the elimination of latent and persistent bacilli.
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Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity.
Yushi Yao,Mangalakumari Jeyanathan,Siamak Haddadi,Nicole G. Barra,Maryam Vaseghi-Shanjani,Daniela Damjanovic,Rocky Lai,Sam Afkhami,Yonghong Chen,Anna Dvorkin-Gheva,Clinton S. Robbins,Jonathan D. Schertzer,Zhou Xing +12 more
TL;DR: It is shown that respiratory viral infection induces long-lasting memory alveolar macrophages, which are programed to express high MHC II, a defense-ready gene signature, and increased glycolytic metabolism, and produce, upon re-stimulation, neutrophil chemokines.
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Influenza Infection Leads to Increased Susceptibility to Subsequent Bacterial Superinfection by Impairing NK Cell Responses in the Lung
Cherrie-Lee Small,Christopher R. Shaler,Sarah McCormick,Mangalakumari Jeyanathan,Daniela Damjanovic,Earl G. Brown,Petra C. Arck,Manel Jordana,Charu Kaushic,Ali A. Ashkar,Zhou Xing +10 more
TL;DR: The weakened NK cell response in the lung is identified to be a novel critical mechanism for flu-mediated susceptibility to bacterial superinfection.
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A Human Type 5 Adenovirus–Based Tuberculosis Vaccine Induces Robust T Cell Responses in Humans Despite Preexisting Anti-Adenovirus Immunity
Fiona Smaill,Mangalakumari Jeyanathan,Marek Smieja,Maria Fe Medina,Niroshan Thanthrige-Don,Anna Zganiacz,Cindy Yin,Armando Heriazon,Daniela Damjanovic,Laura Puri,Jemila S. Hamid,Feng Xie,Ronan Foley,Jonathan L. Bramson,Jack Gauldie,Zhou Xing +15 more
TL;DR: Although AdHu5Ag85A was immunogenic in both trial volunteer groups, it much more potently boosted polyfunctional CD4+ and CD8+ T cell immunity in previously BCG-vaccinated volunteers, suggesting that, at least for certain antigens, adenovirally delivered boosts can enhance the immune response to TB.