Matthias Artaker

TL;DR: It is shown that the activator protein 1 family members JUN and JUNB promote lymphoma development and tumor dissemination through transcriptional regulation of platelet-derived growth factor receptor-β (PDGFRB) in a mouse model of NPM-ALK–triggered lymphomagenesis.

TL;DR: It is shown that in contrast to its tumor-suppressor function in epithelial cells, IGFPB7 can promote anchorage-independent growth in malignant mesenchymal cells and in epitheric cells with an EMT phenotype and can induce colony formation in colon cancer cells co-cultured with IGFBP7-expressing CAFs by a paracrine tumor–stroma interaction.

TL;DR: It is shown for the first time that WNT2 is one of the most significantly induced genes in CRC stroma as compared to normal stroma, and W NT2 and its receptor are classifies as promising stromal targets to confine cancer progression in combination with conventional or targeted therapies.

TL;DR: It is demonstrated that mice completely lacking Stat5 suffer from microcytic anemia due to reduced expression of the antiapoptotic proteins Bcl-x(L) and Mcl-1 followed by enhanced apoptosis, establishing an unexpected mechanistic link between EpoR/Jak/Stat signaling and iron metabolism, processes absolutely essential for erythropoiesis and life.

TL;DR: The data indicate that HDAC1 and HDAC2 have a common function in maintaining proper chromatin structures and show that Hdac2 has a unique role by controlling the fate of neural progenitors during normal brain development.