M
Matthias Hesse
Researcher at National Institutes of Health
Publications - 9
Citations - 2076
Matthias Hesse is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Arginase & Interleukin 10. The author has an hindex of 9, co-authored 9 publications receiving 1988 citations. Previous affiliations of Matthias Hesse include Max Planck Society.
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Journal ArticleDOI
Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of l-Arginine Metabolism
Matthias Hesse,Manuel Modolell,Anne C. La Flamme,Marco Schito,José M. Fuentes,Allen W. Cheever,Edward J. Pearce,Thomas A. Wynn +7 more
TL;DR: An important regulatory role for the arginase biosynthetic pathway in the regulation of inflammation is revealed and differential activation of Arg-1/NOS-2 is a critical determinant in the pathogenesis of granuloma formation.
Journal ArticleDOI
The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells.
Matthias Hesse,Ciriaco A. Piccirillo,Yasmine Belkaid,Jeannette Prufer,Margaret M. Mentink-Kane,Mary Leusink,Allen W. Cheever,Ethan M. Shevach,Thomas A. Wynn +8 more
TL;DR: It is shown that IL-10 is generated by both the innate and adaptive immune response following infection, with both sources regulating the development of type-2 immunity, immune-mediated pathology, and survival of the infected host.
Journal ArticleDOI
IL-13 Activates a Mechanism of Tissue Fibrosis That Is Completely TGF-β Independent
Mallika Kaviratne,Matthias Hesse,Mary Leusink,Allen W. Cheever,Stephen Davies,James H. McKerrow,Lalage M. Wakefield,John J. Letterio,Thomas A. Wynn +8 more
TL;DR: Several genes, including interstitial collagens, several MMPs, and tissue inhibitors of metalloprotease-1 were up-regulated in TGF-β1−/− mice by IL-13, demonstrating thatIL-13 activates the fibrogenic machinery directly.
Journal ArticleDOI
Cutting Edge: Stat6-Dependent Substrate Depletion Regulates Nitric Oxide Production
TL;DR: It is shown that IL-4 and IL-13 regulate NO production through depletion of arginine, the substrate of inducible NO synthase (iNOS), which has implications for understanding the physiological regulation of NO production.
Journal ArticleDOI
NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease
TL;DR: A beneficial role for NOS-2 in the regulation of inflammation is revealed and it is suggested that the ultimate success of Th2-to-Th1 immune deviation strategies will rely on the efficient activation of Nos-2 expression in downstream effector cells.